HUGO name: TCIRG1
Variations / Mutations
Part of the proton channel of V-ATPases (by similarity). Seems to be directly involved in T-cell activation.
The V-ATPase is an heteromultimeric enzyme composed of at least thirteen different subunits. It has a membrane peripheral V1 sector for ATP hydrolysis and an integral V0 for proton translocation. The V1 sector comprises subunits A-H, whereas V0 includes subunits A, D, C, C', and C''.
Membrane; multi-pass membrane protein (by similarity).
Event=alternative splicing; named isoforms=2; name=long; isoid=q13488-1; sequence=displayed; name=short; isoid=q13488-2; sequence=vsp_000345; note=no experimental confirmation available;
The long isoform is highly expressed in osteoclastomas. The short isoform is highly expressed in thymus.
Belongs to the V-ATPase 116 kda subunit family.
Expression pattern for human