LAD-III deficiency involves a general defect in integrin activation. Defects in the activation of β1, β2 and β3 integrin subunits have been observed and it seems that this rare syndrome may be due to several defects in molecules involved in integrin activation. In LAD3 deficiency, the definitive diagnosis is established by the presence of defects in the integrin activation process while the CD18 molecule is structurally intact.
Leukocyte adhesion deficiency type 3
- Defects of phagocyte function
- Leukocyte adhesion defects
Incidence is not known.