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Course description

Aims of the course
This course is intended to give a solid background in structure-related bioinformatics, including a theoretical background in protein modelling. The course is an obligatory requirement for entering our upcoming practical web course on Protein modelling, but serves as an independent theoretical course, too, for anyone who wants to be thoroughly acquainted with macromolecular structure analyses.

Required skills
Before entering this course the student should have a very good knowledge of the principles of protein structure (university-level protein biochemistry) and know the basics about the following topics (e.g. from our Introduction to Bioinformatics)

• Methods of structure determination
• Molecular visualization
• Analysis of structures
• Structural databanks
• Classification databanks
• Multiple sequence alignment
• Secondary structure prediction

You will learn new details of these topics in Structural Bioinformatics, including more serious exercises. We also provide you access to teaching materials from Introduction to Bioinformatics in case you need revision.

Course topics
The above revised topics will form a substantial part of the course, but the main focus of the course will be on:

• Comparison of structures
• Validation of structures
• Molecular modelling, especially homology-based modelling
• Fold recognition (threading)
• Uses of models (both experimental and theoretical models)

Samples