- databases for immunodeficiency-causing mutations
 
 
 

IDbases are locus-specific databases for immunodeficiency-causing mutations. Our aim is to establish database for every immunodeficiency or provide links to those maintained elsewhere.

IDbases contain in addition to gene mutation, also information about clinical presentation. Information has been collected from literature as well as received directly from researchers. We would be most glad if those analysing mutations would send their information by using the interactive web submission available in each database. A number of articles have been published related to IDbases. IDbases are curated and distributed with proprietary MUTbase software suite.

We maintain 131  public IDbases
These databases contain altogether data for 17  patients
Immunodeficiency mutation databases maintained by others: 27  databases [ link list ]
Human Mutation

Piirilä H., Väliaho J., Vihinen M.
Immunodeficiency mutation databases (IDbases)
Hum. Mutat. 2006 Sep 26;27(12):1200-1208

Freely available by clicking the journal cover above

"Rating: Very good"
Website Review in Genetic Engineering News September 15, 2005 by Kevin Ahern




Deficiencies predominantly affecting antibody production
Combined B and T cell immunodeficiencies
Defects in lymphocyte apoptosis
Other well-defined immunodeficiency syndromes
Defects of phagocyte function
Defects of innate immune system, receptors and signaling components
DNA breakage associated syndromes and DNA epigenetic modification syndromes



IDbases are linked to University of California Santa Cruz (UCSC) Genome browser. Giardine et.al. Hum Mutat. 2007 Feb 26;28(6):554-562
IDbases and ESID Patient Registry are connected. You can submit mutation information also via ESID registry.

We are most grateful for the financial support from EU and Medical Research Fund of Tampere University Hospital.


Last updated: 09.04.2013