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- databases for immunodeficiency-causing mutations

   STX11base
   Mutation registry for  Familial haemophagocytic lymphohistiocytosis 4


Database        STX11base
Version         1.0
File            stx11pub.html
Date            16-Jun-2011
Curator         Mauno Vihinen
Address         Institute of Medical Technology 
Address         FI-33014 University of Tampere, Finland
Phone           +358-3-3551 7735
Fax             +358-3-3551 7710
Email           Mauno.Vihinen@uta.fi
URL             http://bioinf.uta.fi/STX11base/
FTP             ftp://protein.uta.fi/pub/stx11pub.dat
IDR factfile    http://bioinf.uta.fi/xml/idr/ff/FF155.xml
Gene            STX11
Disease         Familial haemophagocytic lymphohistiocytosis 4 (FHL4) 
OMIM            605014
Sequence        IDRefSeq:D0083; IDRefSeq:C0083; UniProt:O75558 
Numbering       start of the entry
Funding         Tampere University Hospital Medical Research Fund
Funding         European Union
Comments        sequence entry reference in every entry
//
ID              #T37X62(1),#T37X62(1); standard; MUTATION;
Accession       S0014
Systematic name Allele 1 and 2: g.37206delC, c.110delC, r.110delc,
Systematic name p.Thr37fsX26
Original code   P.4
Description     Allele 1 and 2: A frame shift deletion mutation in the exon
Description     2 leading to a premature stop codon
Date            07-Jul-2010 (Rel. 1, Created)
Date            07-Jul-2010 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 17525286
RefAuthors      Bryceson, Y. T., Rudd, E., Zheng, C., Edner, J., Ma, D., 
RefAuthors      Wood, S. M., Bechensteen, A. G., Boelens, J. J., Celkan, 
RefAuthors      T., Farah, R. A., Hultenby, K., Winiarski, J., Roche, P. 
RefAuthors      A., Nordenskjold, M., Henter, J. I., Long, E. O., 
RefAuthors      Ljunggren, H. G.
RefTitle        Defective cytotoxic lymphocyte degranulation in syntaxin-
RefTitle        11 deficient familial hemophagocytic lymphohistiocytosis 
RefTitle        4 (FHL4) patients.
RefLoc          Blood:1906-1915 (2007)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: deletion
Feature           /loc: IDRefSeq: D0083: 37206
Feature           /change: -c
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083; GI:33667037; STX11C: 287
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 37
Feature           /change: T -> RTTSWSPCTE TSGTFRMKTS CWWPTX
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: deletion
Feature           /loc: IDRefSeq: D0083: 37206
Feature           /change: -c
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083; GI:33667037; STX11C: 287
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 37
Feature           /change: T -> RTTSWSPCTE TSGTFRMKTS CWWPTX
Symptoms        Fever, splenomegaly, pancytopenia, hypertriglyceridemia,
Symptoms        hypofibrinogenemiahemophagocytosis
Age             7/12
Sex             XY
Ethnic origin   Lebanon
Parents         Consanguineous
Comment         Patient is alive and well after stem cell transplantation.
//
ID              #A123X183(1a),#A123X183(1a); standard; MUTATION;
Accession       S0001
Systematic name Allele 1 and 2: g.37465_37472delinsTGG, c.369_376delinsTGG,
Systematic name r.369_376delinsugg, p.Val124fsX60
Original code   Family 1, IV:8
Description     Allele 1 and 2: a frame shift indel mutation in the exon 2
Description     leading to a premature stop codon
Date            01-Mar-2005 (Rel. 1, Created)
Date            01-Mar-2005 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 15703195
RefAuthors      Zur Stadt, U., Schmidt, S., Kasper, B., Beutel, K., Diler, 
RefAuthors      A. S., Henter, J. I., Kabisch, H., Schneppenheim, R., 
RefAuthors      Nurnberg, P., Janka, G., Hennies, H. C.
RefTitle        Linkage of familial hemophagocytic lymphohistiocytosis  
RefTitle        (FHL) type-4 to chromosome 6q24 and identification of  
RefTitle        mutations in syntaxin 11.
RefLoc          Hum Mol Genet 14(6):827-834(2005)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
Age             12 mo
Sex             XY
Ethnic origin   Caucasoid; Kurdish
Parents         Consanguineous
Family history  Inherited
Relative        STX11base; S0002 brother
Relative        STX11base; S0003 second cousin once removed
Relative        STX11base; S0004 second cousin once removed
Relative        STX11base; S0005 second cousin once removed
//
ID              #A123X183(1b),#A123X183(1b); standard; MUTATION;
Accession       S0002
Systematic name Allele 1 and 2: g.37465_37472delinsTGG, c.369_376delinsTGG,
Systematic name r.369_376delinsugg, p.Val124fsX60
Original code   Family 1, IV:9
Description     Allele 1 and 2: a frame shift indel mutation in the exon 2
Description     leading to a premature stop codon
Date            01-Mar-2005 (Rel. 1, Created)
Date            01-Mar-2005 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 15703195
RefAuthors      Zur Stadt, U., Schmidt, S., Kasper, B., Beutel, K., Diler, 
RefAuthors      A. S., Henter, J. I., Kabisch, H., Schneppenheim, R., 
RefAuthors      Nurnberg, P., Janka, G., Hennies, H. C.
RefTitle        Linkage of familial hemophagocytic lymphohistiocytosis  
RefTitle        (FHL) type-4 to chromosome 6q24 and identification of  
RefTitle        mutations in syntaxin 11.
RefLoc          Hum Mol Genet 14(6):827-834(2005)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
Age             39 mo
Sex             XY
Ethnic origin   Caucasoid; Kurdish
Parents         Consanguineous
Family history  Inherited
Relative        STX11base; S0001 brother
Relative        STX11base; S0003 second cousin once removed
Relative        STX11base; S0004 second cousin once removed
Relative        STX11base; S0005 second cousin once removed
//
ID              #A123X183(1c),#A123X183(1c); standard; MUTATION;
Accession       S0003
Systematic name Allele 1 and 2: g.37465_37472delinsTGG, c.369_376delinsTGG,
Systematic name r.369_376delinsugg, p.Val124fsX60
Original code   Family 1, V:1
Description     Allele 1 and 2: a frame shift indel mutation in the exon 2
Description     leading to a premature stop codon
Date            01-Mar-2005 (Rel. 1, Created)
Date            01-Mar-2005 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 15703195
RefAuthors      Zur Stadt, U., Schmidt, S., Kasper, B., Beutel, K., Diler, 
RefAuthors      A. S., Henter, J. I., Kabisch, H., Schneppenheim, R., 
RefAuthors      Nurnberg, P., Janka, G., Hennies, H. C.
RefTitle        Linkage of familial hemophagocytic lymphohistiocytosis  
RefTitle        (FHL) type-4 to chromosome 6q24 and identification of  
RefTitle        mutations in syntaxin 11.
RefLoc          Hum Mol Genet 14(6):827-834(2005)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
Age             24 mo
Sex             XY
Ethnic origin   Caucasoid; Kurdish
Parents         Consanguineous
Family history  Inherited
Relative        STX11base; S0001 second cousin once removed
Relative        STX11base; S0002 second cousin once removed
Relative        STX11base; S0004 sister
Relative        STX11base; S0005 sister
//
ID              #A123X183(1d),#A123X183(1d); standard; MUTATION;
Accession       S0004
Systematic name Allele 1 and 2: g.37465_37472delinsTGG, c.369_376delinsTGG,
Systematic name r.369_376delinsugg, p.Val124fsX60
Original code   Family 1, V:2
Description     Allele 1 and 2: a frame shift indel mutation in the exon 2
Description     leading to a premature stop codon
Date            01-Mar-2005 (Rel. 1, Created)
Date            01-Mar-2005 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 15703195
RefAuthors      Zur Stadt, U., Schmidt, S., Kasper, B., Beutel, K., Diler, 
RefAuthors      A. S., Henter, J. I., Kabisch, H., Schneppenheim, R., 
RefAuthors      Nurnberg, P., Janka, G., Hennies, H. C.
RefTitle        Linkage of familial hemophagocytic lymphohistiocytosis  
RefTitle        (FHL) type-4 to chromosome 6q24 and identification of  
RefTitle        mutations in syntaxin 11.
RefLoc          Hum Mol Genet 14(6):827-834(2005)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
Age             5 mo
Sex             XX
Ethnic origin   Caucasoid; Kurdish
Parents         Consanguineous
Family history  Inherited
Relative        STX11base; S0001 second cousin once removed
Relative        STX11base; S0002 second cousin once removed
Relative        STX11base; S0003 brother
Relative        STX11base; S0005 twinsister
//
ID              #A123X183(1e),#A123X183(1e); standard; MUTATION;
Accession       S0005
Systematic name Allele 1 and 2: g.37465_37472delinsTGG, c.369_376delinsTGG,
Systematic name r.369_376delinsugg, p.Val124fsX60
Original code   Family 1, V:3
Description     Allele 1 and 2: a frame shift indel mutation in the exon 2
Description     leading to a premature stop codon
Date            01-Mar-2005 (Rel. 1, Created)
Date            01-Mar-2005 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 15703195
RefAuthors      Zur Stadt, U., Schmidt, S., Kasper, B., Beutel, K., Diler, 
RefAuthors      A. S., Henter, J. I., Kabisch, H., Schneppenheim, R., 
RefAuthors      Nurnberg, P., Janka, G., Hennies, H. C.
RefTitle        Linkage of familial hemophagocytic lymphohistiocytosis  
RefTitle        (FHL) type-4 to chromosome 6q24 and identification of  
RefTitle        mutations in syntaxin 11.
RefLoc          Hum Mol Genet 14(6):827-834(2005)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
Age             14 mo
Sex             XX
Ethnic origin   Caucasoid; Kurdish
Parents         Consanguineous
Family history  Inherited
Relative        STX11base; S0001 second cousin once removed
Relative        STX11base; S0002 second cousin once removed
Relative        STX11base; S0003 brother
Relative        STX11base; S0004 twinsister
//
ID              #A123X183(2),#A123X183(2); standard; MUTATION;
Accession       S0006
Systematic name Allele 1 and 2: g.37465_37472delinsTGG, c.369_376delinsTGG,
Systematic name r.369_376delinsugg, p.Val124fsX60
Original code   Family 2
Description     Allele 1 and 2: a frame shift indel mutation in the exon 2
Description     leading to a premature stop codon
Date            01-Mar-2005 (Rel. 1, Created)
Date            01-Mar-2005 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 15703195
RefAuthors      Zur Stadt, U., Schmidt, S., Kasper, B., Beutel, K., Diler, 
RefAuthors      A. S., Henter, J. I., Kabisch, H., Schneppenheim, R., 
RefAuthors      Nurnberg, P., Janka, G., Hennies, H. C.
RefTitle        Linkage of familial hemophagocytic lymphohistiocytosis  
RefTitle        (FHL) type-4 to chromosome 6q24 and identification of  
RefTitle        mutations in syntaxin 11.
RefLoc          Hum Mol Genet 14(6):827-834(2005)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
Age             13 mo
Sex             XY
Ethnic origin   Caucasoid; Kurdish
Parents         Consanguineous
Family history  Inherited
//
ID              #A123X183(3),#A123X183(3); standard; MUTATION;
Accession       S0007
Systematic name Allele 1 and 2: g.37465_37472delinsTGG, c.369_376delinsTGG,
Systematic name r.369_376delinsugg, p.Val124fsX60
Original code   Family 3
Description     Allele 1 and 2: a frame shift indel mutation in the exon 2
Description     leading to a premature stop codon
Date            01-Mar-2005 (Rel. 1, Created)
Date            01-Mar-2005 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 15703195
RefAuthors      Zur Stadt, U., Schmidt, S., Kasper, B., Beutel, K., Diler, 
RefAuthors      A. S., Henter, J. I., Kabisch, H., Schneppenheim, R., 
RefAuthors      Nurnberg, P., Janka, G., Hennies, H. C.
RefTitle        Linkage of familial hemophagocytic lymphohistiocytosis  
RefTitle        (FHL) type-4 to chromosome 6q24 and identification of  
RefTitle        mutations in syntaxin 11.
RefLoc          Hum Mol Genet 14(6):827-834(2005)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
Age             7 mo
Sex             XX
Ethnic origin   Caucasoid; Kurdish
Parents         Consanguineous
Family history  Inherited
//
ID              #A123X183(4a),#A123X183(4a); standard; MUTATION;
Accession       S0011
Systematic name Allele 1 and 2: g.37465_37472delinsTGG, c.369_376delinsTGG,
Systematic name r.369_376delinsugg,  p.Val124fsX60
Original code   B1
Description     Allele 1 and 2: A frame shift indel mutation in the exon 2
Description     leading to a premature stop codon
Date            15-Sep-2006 (Rel. 1, Created)
Date            15-Sep-2006 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 16582076
RefAuthors      Rudd, E., Goransdotter Ericson, K., Zheng, C., Uysal, Z., 
RefAuthors      Ozkan, A., Gurgey, A., Fadeel, B., Nordenskjold, M., 
RefAuthors      Henter, J. I.
RefTitle        Spectrum and clinical implications of syntaxin 11 gene 
RefTitle        mutations in familial haemophagocytic lymphohistiocytosis: 
RefTitle        association with disease-free remissions and 
RefTitle        haematopoietic malignancies.
RefLoc          J Med Genet 43:e14 (2006)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
Symptoms        Severe psychomotor retardation, hepatosplenomegaly,
Symptoms        residual hypertriglyceridaemia
Age             5 mo
Sex             XX
Ethnic origin   Caucasoid; Turkey
Parents         Consanguineous
Family history  Inherited
Relative        STX11base; S0012 brother
//
ID              #A123X183(4b),#A123X183(4b); standard; MUTATION;
Accession       S0012
Systematic name Allele 1 and 2: g.37465_37472delinsTGG, c.369_376delinsTGG,
Systematic name r.369_376delinsugg,  p.Val124fsX60
Original code   B2
Description     Allele 1 and 2: A frame shift indel mutation in the exon 2
Description     leading to a premature stop codon
Date            15-Sep-2006 (Rel. 1, Created)
Date            15-Sep-2006 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 16582076
RefAuthors      Rudd, E., Goransdotter Ericson, K., Zheng, C., Uysal, Z., 
RefAuthors      Ozkan, A., Gurgey, A., Fadeel, B., Nordenskjold, M., 
RefAuthors      Henter, J. I.
RefTitle        Spectrum and clinical implications of syntaxin 11 gene 
RefTitle        mutations in familial haemophagocytic lymphohistiocytosis: 
RefTitle        association with disease-free remissions and 
RefTitle        haematopoietic malignancies.
RefLoc          J Med Genet 43:e14 (2006)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: indel
Feature           /loc: IDRefSeq: D0083: 37465..37472
Feature           /change: agtggcgc -> tgg
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083: 546..553
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 123..126
Feature           /change: AVAR -> 
Feature           /change: AGHFAGAVQR AHPHLPARHA RLQPGRDEAA RQLQDPHPAP
Feature           /change: AGDHGQGSLG RPDRGHVRAG X
Symptoms        Severe psychomotor retardation, hepatosplenomegaly
Age             6 mo
Sex             XY
Ethnic origin   Caucasoid; Turkey
Parents         Consanguineous
Family history  Inherited
Relative        STX11base; S0011 sister
//
ID              #L194X196(1),#L194X196(1); standard; MUTATION;
Accession       S0017
Systematic name Allele 1 and 2: g.37677_37680delTGGC, c.581_584delTGGC,
Systematic name r.581_584deluggc, p.Leu194fsX3
Original code   P.1
Description     Allele 1 and 2: A frame shift deletion mutation in the exon
Description     2 leading to a premature stop codon
Date            07-Jul-2010 (Rel. 1, Created)
Date            07-Jul-2010 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 19967551
RefAuthors      Danielian, S., Basile, N., Rocco, C., Prieto, E., Rossi, 
RefAuthors      J., Barsotti, D., Roche, P. A., Bernasconi, A., Oleastro, 
RefAuthors      M., Zelazko, M., Braier, J.
RefTitle        Novel syntaxin 11 gene (STX11) mutation in three 
RefTitle        argentinean patients with hemophagocytic 
RefTitle        lymphohistiocytosis.
RefLoc          J Clin Immunol:330-337 (2010)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: deletion
Feature           /loc: IDRefSeq: D0083: 37677..37680
Feature           /change: -tggc
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083; GI:33667037; STX11C: 758..761
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 194..195
Feature           /change: LA -> PTX
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: deletion
Feature           /loc: IDRefSeq: D0083: 37677..37680
Feature           /change: -tggc
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083; GI:33667037; STX11C: 758..761
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 194..195
Feature           /change: LA -> PTX
Symptoms        Fever, hepatosplenomegaly, cytopenia, anaemia, neutropenia,
Symptoms        thrombocytopenia, hypertriglyceridemia, coagulopathy,
Symptoms        enlarged lymph nodes
Age             1.6
Sex             XX
Ethnic origin   Argentina
Parents         Non-consanguineous
Comment         Patient died of transplant-related complications.
//
ID              #L194X196(2),#L194X196(2); standard; MUTATION;
Accession       S0018
Systematic name Allele 1 and 2: g.37677_37680delTGGC, c.581_584delTGGC,
Systematic name r.581_584deluggc, p.Leu194fsX3
Original code   P.2
Description     Allele 1 and 2: A frame shift deletion mutation in the exon
Description     2 leading to a premature stop codon
Date            07-Jul-2010 (Rel. 1, Created)
Date            07-Jul-2010 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 19967551
RefAuthors      Danielian, S., Basile, N., Rocco, C., Prieto, E., Rossi, 
RefAuthors      J., Barsotti, D., Roche, P. A., Bernasconi, A., Oleastro, 
RefAuthors      M., Zelazko, M., Braier, J.
RefTitle        Novel syntaxin 11 gene (STX11) mutation in three 
RefTitle        argentinean patients with hemophagocytic 
RefTitle        lymphohistiocytosis.
RefLoc          J Clin Immunol:330-337 (2010)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: deletion
Feature           /loc: IDRefSeq: D0083: 37677..37680
Feature           /change: -tggc
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083; GI:33667037; STX11C: 758..761
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 194..195
Feature           /change: LA -> PTX
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: deletion
Feature           /loc: IDRefSeq: D0083: 37677..37680
Feature           /change: -tggc
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083; GI:33667037; STX11C: 758..761
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 194..195
Feature           /change: LA -> PTX
Symptoms        Fever, cytopenia, hepatosplenomegaly, cutaneous rash,
Symptoms        cholestatic hepatitis
Age             1.1
Sex             XX
Ethnic origin   Argentina
Parents         Non-consanguineous
//
ID              #L194X196(3),#L194X196(3); standard; MUTATION;
Accession       S0019
Systematic name Allele 1 and 2: g.37677_37680delTGGC, c.581_584delTGGC,
Systematic name r.581_584deluggc, p.Leu194fsX3
Original code   P.3
Description     Allele 1 and 2: A frame shift deletion mutation in the exon
Description     2 leading to a premature stop codon
Date            07-Jul-2010 (Rel. 1, Created)
Date            07-Jul-2010 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 19967551
RefAuthors      Danielian, S., Basile, N., Rocco, C., Prieto, E., Rossi, 
RefAuthors      J., Barsotti, D., Roche, P. A., Bernasconi, A., Oleastro, 
RefAuthors      M., Zelazko, M., Braier, J.
RefTitle        Novel syntaxin 11 gene (STX11) mutation in three 
RefTitle        argentinean patients with hemophagocytic 
RefTitle        lymphohistiocytosis.
RefLoc          J Clin Immunol:330-337 (2010)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: deletion
Feature           /loc: IDRefSeq: D0083: 37677..37680
Feature           /change: -tggc
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083; GI:33667037; STX11C: 758..761
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 194..195
Feature           /change: LA -> PTX
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: deletion
Feature           /loc: IDRefSeq: D0083: 37677..37680
Feature           /change: -tggc
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: frameshift
Feature           /loc: IDRefSeq: C0083; GI:33667037; STX11C: 758..761
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 194..195
Feature           /change: LA -> PTX
Symptoms        Fever, cervical lymphadenopathy, hepatosplenomegaly,
Symptoms        pancytopenia, cutaneous rash
Age             3
Sex             XX
Ethnic origin   Argentina
Parents         Consanguineous
//
ID              Q268X(1),Q268X(1); standard; MUTATION;
Accession       S0008
Systematic name Allele 1 and 2: g.37898C>T, c.802C>T, r.802c>u, p.Gln268X
Original code   Family 5
Description     Allele 1 and 2: a point mutation in the exon 2 leading to a
Description     premature stop codon
Date            01-Mar-2005 (Rel. 1, Created)
Date            01-Mar-2005 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 15703195
RefAuthors      Zur Stadt, U., Schmidt, S., Kasper, B., Beutel, K., Diler, 
RefAuthors      A. S., Henter, J. I., Kabisch, H., Schneppenheim, R., 
RefAuthors      Nurnberg, P., Janka, G., Hennies, H. C.
RefTitle        Linkage of familial hemophagocytic lymphohistiocytosis  
RefTitle        (FHL) type-4 to chromosome 6q24 and identification of  
RefTitle        mutations in syntaxin 11.
RefLoc          Hum Mol Genet 14(6):827-834(2005)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: point
Feature           /loc: IDRefSeq: D0083: 37898
Feature           /change: c -> t
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: nonsense
Feature           /loc: IDRefSeq: C0083: 979
Feature           /codon: cag -> tag; 1
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 268
Feature           /change: Q -> X
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: point
Feature           /loc: IDRefSeq: D0083: 37898
Feature           /change: c -> t
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: nonsense
Feature           /loc: IDRefSeq: C0083: 979
Feature           /codon: cag -> tag; 1
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 268
Feature           /change: Q -> X
Age             16 mo
Sex             XY
Ethnic origin   Caucasoid; Kurdish
Parents         Consanguineous
Family history  Inherited
//
ID              Q268X(2),Q268X(2); standard; MUTATION;
Accession       S0009
Systematic name Allele 1 and 2: g.37898C>T, c.802C>T, r.802c>u, p.Gln268X
Original code   Family 6
Description     Allele 1 and 2: a point mutation in the exon 2 leading to a
Description     premature stop codon
Date            01-Mar-2005 (Rel. 1, Created)
Date            01-Mar-2005 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 15703195
RefAuthors      Zur Stadt, U., Schmidt, S., Kasper, B., Beutel, K., Diler, 
RefAuthors      A. S., Henter, J. I., Kabisch, H., Schneppenheim, R., 
RefAuthors      Nurnberg, P., Janka, G., Hennies, H. C.
RefTitle        Linkage of familial hemophagocytic lymphohistiocytosis  
RefTitle        (FHL) type-4 to chromosome 6q24 and identification of  
RefTitle        mutations in syntaxin 11.
RefLoc          Hum Mol Genet 14(6):827-834(2005)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: point
Feature           /loc: IDRefSeq: D0083: 37898
Feature           /change: c -> t
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: nonsense
Feature           /loc: IDRefSeq: C0083: 979
Feature           /codon: cag -> tag; 1
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 268
Feature           /change: Q -> X
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: point
Feature           /loc: IDRefSeq: D0083: 37898
Feature           /change: c -> t
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: nonsense
Feature           /loc: IDRefSeq: C0083: 979
Feature           /codon: cag -> tag; 1
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 268
Feature           /change: Q -> X
Age             1,5 mo
Sex             XX
Ethnic origin   Caucasoid; Kurdish
Parents         Consanguineous
Family history  Inherited
//
ID              Q268X(3),Q268X(3); standard; MUTATION;
Accession       S0013
Systematic name Allele 1 and 2: g.37898C>T, c.802C>T, r.802c>u,  p.Gln268X
Original code   D1
Description     Allele 1 and 2: A point mutation in the exon 2 leading to a
Description     premature stop codon
Date            15-Sep-2006 (Rel. 1, Created)
Date            15-Sep-2006 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 16582076
RefAuthors      Rudd, E., Goransdotter Ericson, K., Zheng, C., Uysal, Z., 
RefAuthors      Ozkan, A., Gurgey, A., Fadeel, B., Nordenskjold, M., 
RefAuthors      Henter, J. I.
RefTitle        Spectrum and clinical implications of syntaxin 11 gene 
RefTitle        mutations in familial haemophagocytic lymphohistiocytosis: 
RefTitle        association with disease-free remissions and 
RefTitle        haematopoietic malignancies.
RefLoc          J Med Genet 43:e14 (2006)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: point
Feature           /loc: IDRefSeq: D0083: 37898
Feature           /change: c -> t
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: nonsense
Feature           /loc: IDRefSeq: C0083: 979
Feature           /codon: cag -> tag; 1
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 268
Feature           /change: Q -> X
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: point
Feature           /loc: IDRefSeq: D0083: 37898
Feature           /change: c -> t
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: nonsense
Feature           /loc: IDRefSeq: C0083: 979
Feature           /codon: cag -> tag; 1
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 268
Feature           /change: Q -> X
Symptoms        Fever, splenomegaly,hepatomegaly, anaemia,
Symptoms        thrombocytopenia, haemophagocytosis, neutropenia,
Symptoms        hypofibrinogenaemia
Age             7
Sex             XY
Ethnic origin   Caucasoid; Turkey
Parents         Consanguineous
Family history  Inherited
Comment         Patient died.
//
ID              Q268X(4),Q268X(4); standard; MUTATION;
Accession       S0015
Systematic name Allele 1 and 2: g.37898C>T, c.802C>T, r.802c>u, p.Gln268X
Original code   P.5
Description     Allele 1 and 2: A point mutation in the exon 2 leading to a
Description     premature stop codon
Date            07-Jul-2010 (Rel. 1, Created)
Date            07-Jul-2010 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 17525286
RefAuthors      Bryceson, Y. T., Rudd, E., Zheng, C., Edner, J., Ma, D., 
RefAuthors      Wood, S. M., Bechensteen, A. G., Boelens, J. J., Celkan, 
RefAuthors      T., Farah, R. A., Hultenby, K., Winiarski, J., Roche, P. 
RefAuthors      A., Nordenskjold, M., Henter, J. I., Long, E. O., 
RefAuthors      Ljunggren, H. G.
RefTitle        Defective cytotoxic lymphocyte degranulation in syntaxin-
RefTitle        11 deficient familial hemophagocytic lymphohistiocytosis 
RefTitle        4 (FHL4) patients.
RefLoc          Blood:1906-1915 (2007)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: point
Feature           /loc: IDRefSeq: D0083: 37898
Feature           /change: c -> t
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: nonsense
Feature           /loc: IDRefSeq: C0083; GI:33667037; STX11C: 979
Feature           /codon: cag -> tag; 1
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 268
Feature           /change: Q -> X
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: point
Feature           /loc: IDRefSeq: D0083: 37898
Feature           /change: c -> t
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: nonsense
Feature           /loc: IDRefSeq: C0083; GI:33667037; STX11C: 979
Feature           /codon: cag -> tag; 1
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 268
Feature           /change: Q -> X
Symptoms        Fever, splenomegaly, pancytopenia, hypertriglyceridemia,
Symptoms        hypofibrinogenaemia
Age             6
Sex             XY
Ethnic origin   Turkey
Parents         Consanguineous
Comment         Patient is alive and well after stem cell transplantation.
//
ID              Q268X(5),Q268X(5); standard; MUTATION;
Accession       S0016
Systematic name Allele 1 and 2: g.37898C>T, c.802C>T, r.802c>u, p.Gln268X
Original code   C:1
Description     Allele 1 and 2: A point mutation in the exon 2 leading to a
Description     premature stop codon
Date            07-Jul-2010 (Rel. 1, Created)
Date            07-Jul-2010 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 16582076
RefAuthors      Rudd, E., Goransdotter Ericson, K., Zheng, C., Uysal, Z., 
RefAuthors      Ozkan, A., Gurgey, A., Fadeel, B., Nordenskjold, M., 
RefAuthors      Henter, J. I.
RefTitle        Spectrum and clinical implications of syntaxin 11 gene 
RefTitle        mutations in familial haemophagocytic lymphohistiocytosis: 
RefTitle        association with disease-free remissions and 
RefTitle        haematopoietic malignancies.
RefLoc          J Med Genet:e14 (2006)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: point
Feature           /loc: IDRefSeq: D0083: 37898
Feature           /change: c -> t
Feature           /genomic_region: exon; 2
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: nonsense
Feature           /loc: IDRefSeq: C0083; GI:33667037; STX11C: 979
Feature           /codon: cag -> tag; 1
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 268
Feature           /change: Q -> X
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: point
Feature           /loc: IDRefSeq: D0083: 37898
Feature           /change: c -> t
Feature           /genomic_region: exon; 2
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: nonsense
Feature           /loc: IDRefSeq: C0083; GI:33667037; STX11C: 979
Feature           /codon: cag -> tag; 1
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: out of frame translation; premature termination
Feature           /loc: UniProt: O75558; STX11_HUMAN: 268
Feature           /change: Q -> X
Symptoms        Fever, splenomegaly,hepatomegaly, anaemia,
Symptoms        thrombocytopenia, haemophagocytosis hypofibrinogenaemia,
Symptoms        haemophagocytosis
Age             1 mo
Sex             XX
Ethnic origin   Turkey
Parents         Consanguineous
Family history  Inherited
Comment         Patient is alive and well.
//
ID              Deletion(1),Deletion(1); standard; MUTATION; 
Accession       S0010
Systematic name Allele 1 and 2: g.27357..46546del
Original code   Family 4
Description     Allele 1 and 2: a large deletion in the intron 1 and the  
Description     entire coding region of STX11
Date            18-Mar-2005 (Rel. 1, Created)
Date            18-Mar-2005 (Rel. 1, Last updated, Version 1)
RefNumber       [1]
RefCrossRef     PUBMED; 15703195
RefAuthors      Zur Stadt, U., Schmidt, S., Kasper, B., Beutel, K., Diler, 
RefAuthors      A. S., Henter, J. I., Kabisch, H., Schneppenheim, R., 
RefAuthors      Nurnberg, P., Janka, G., Hennies, H. C.
RefTitle        Linkage of familial hemophagocytic lymphohistiocytosis  
RefTitle        (FHL) type-4 to chromosome 6q24 and identification of  
RefTitle        mutations in syntaxin 11.
RefLoc          Hum Mol Genet 14(6):827-834(2005)
FeatureHeader   allele; 1
Feature         dna; 1
Feature           /rnalink: 2
Feature           /name: deletion
Feature           /loc: IDRefSeq: D0083: 27357..46546
Feature           /change: -tacttacatg gaaaaccctc atgcattgat gatgttggat
Feature           /change:  aactcagata tttccgtacc ttgtgtaaaa gatatcagcc
Feature           /change:  atatataaga atattttttc tgggagaatt taacaggagt
Feature           /change:  aaccaggcaa tgagactaga ataagtggcc caaaggacac
Feature           /change:  tgtttacaag aaagaggaac agataaagga atgtaaaaat
Feature           /change:  tcttaactgg tgttacgagt tggaaaagaa aaggtcattg
Feature           /change:  atgattctgg aaactccatg gatttctccc tttcaaagat
Feature           /change:  acttcatgga atagttacaa aatataaagg aattacttaa
Feature           /change:  aggcatatat gttttccaac tggactcaaa atctattccc
Feature           /change:  catcattttt taaacataga tctttgctgt attttccagg
Feature           /change:  caaagttttg cttcacattc tagggccaaa gggaaatcag
Feature           /change:  atgtaagagt tacaacaact gttttagttt gtaaatacta
Feature           /change:  atagagatac aagtggaaaa atttgcacag atgacttgag
Feature           /change:  ccttgaggcc ttgacccttg agtgctcctg tctttacttt
Feature           /change:  ctcccttagc tcatctactg gctgggagcg gtggctcacg
Feature           /change:  cctgtaatcc cagcactttg ggaggctgag gcaggcggat
Feature           /change:  cacaaggtca ggagtttgag accaacctgg ccaatatagt
Feature           /change:  gaaaccccat ctctactaaa aacacacaaa aaattagccg
Feature           /change:  ggtgtggtgg tgcacacctg taatcccagc tactcaggag
Feature           /change:  gctgaggcag gagaattgct tgaacccggg aggcaaaggt
Feature           /change:  tgcggtgagc caagattgca ccactgcact ccagcctggg
Feature           /change:  tgacagaggg agactccgtc tcaaaaaaaa gaagaaagaa
Feature           /change:  agctcatcta ctgtcctttc ctgctgtggc ttctatgcac
Feature           /change:  ctgactgtaa aatttacatc tccaagtgtc tgtattctgt
Feature           /change:  tatttcagag agttaataat tttatggatt ttttttaaag
Feature           /change:  ttgtggtgac ttactccctg tttttaggac tgtaacaact
Feature           /change:  gaagtgttgc aatgttgggg aaactctgat atgaagaaat
Feature           /change:  ttgtgtggga aagaaagtag tgattctaat ggtgacagta
Feature           /change:  tttccatgtg ttaatccagt tctaagaatt agatgctaat
Feature           /change:  aattgttcct aatagaaaag ctcaattagg gaatacgttt
Feature           /change:  cctattagac taacgatttt aaaagaagcc ttcttgtggg
Feature           /change:  gagtttagga aaaagaagct agtgtagctt tgtggattac
Feature           /change:  ggatggattc tcaagtagtc acacttttgg gatttatatc
Feature           /change:  tcaactccat aactgtatga ctttaggcaa actgcttaaa
Feature           /change:  ctcattaggc ctcaaacctg tagactgggg atgatgataa
Feature           /change:  tacctcataa ggaataaatg ggttaatacc tgcccattgc
Feature           /change:  tgagtaccgc atttggcatt ttacaaatgc ttaataaatg
Feature           /change:  ttcactgtag agcagaatgt atgaaaccta cacaggagta
Feature           /change:  gctgctttga tttcccgtgc atttctacag aaagcatctg
Feature           /change:  aaagcatatt gctaaaagtg aaatcccagc tacccactgg
Feature           /change:  ctgtttatca actgtgcata tcaaactgcc tttttctctt
Feature           /change:  cacacactgg cagaaaattc tgattgagga aactgaaaag
Feature           /change:  cgaattatgt cagagggcat caaatgagta aagtgattga
Feature           /change:  aaagtagagg ctgtctcctc cagcagtggt ttgaataact
Feature           /change:  cctacctgct ttctgcttta gagcaaagag aaaacaagag
Feature           /change:  acatttaaaa attatttctt ctagcctcag acttttatcg
Feature           /change:  ttataaacca tttcaattaa tactcttcag cctttcaaat
Feature           /change:  tttgctttga atgagcccta agacaatatt aaatgcgttc
Feature           /change:  ttgcccaatg cactttaaga tacgatacaa gctttttttt
Feature           /change:  ttttaaatta acttcggagc agcaagaaaa ttagagctat
Feature           /change:  tcattaggaa ctttttagtt ttaacctgta atgttttgat
Feature           /change:  gttcaaagaa tagtgtttcc ctctgtatta gtctgttttc
Feature           /change:  atgctgctga taaagacata tctgagactg ggcaatttac
Feature           /change:  aaaagaaaga ggtttaatgg acttacagtt ccacgtggct
Feature           /change:  ggggagaact tacaatcatg gtgaggcaat ggtgaggcat
Feature           /change:  ggtgaatgca aggaggggca agtcacatct tatgtggatg
Feature           /change:  gtggcagaca aaaagagaat gaagaggatg caaaagcaga
Feature           /change:  aacctctaat aaaaccatca gatctcatga cacttattca
Feature           /change:  ctaccaccag aacagcatgg gggaaaccgc ccccatgatt
Feature           /change:  cagttatctc ccaccggatc cctcgcacaa cgtgtgggaa
Feature           /change:  ttatgggagt accattcaag atgagatttg ggtggggaca
Feature           /change:  tagagccaaa ccatatcacc ctcttagatg tgtcatttta
Feature           /change:  aaaatcaaga aacagaacac tggttttact cagttgagtg
Feature           /change:  aaattattgt ttatgaacct gttggggaaa gtccatttgt
Feature           /change:  tgttctttaa gggctgtgtt actatggggt atgctagaaa
Feature           /change:  ggaactgcta aattacagtg acactctacc tgtggaattt
Feature           /change:  ctaggtgcct ctggtagcgg ggatgtgtgg gcaggaggga
Feature           /change:  ctggatgagg tggttgagaa aggggtacac agggtgaccc
Feature           /change:  catggggctg tgcaggttgt gatctcacca cagatgagag
Feature           /change:  agactggcaa tccaaccatg ctcagctcac caggatgcat
Feature           /change:  gcccttgggc agggctttat ccacccagag aaagggccct
Feature           /change:  ttcctagctt tcacaaagat actatataag cccaacacaa
Feature           /change:  aacctcatta aggcacccta tagaccaata gtggaccttc
Feature           /change:  tgatttgtaa taatcacttt aatcatatgt ttacaattgg
Feature           /change:  tataaaatta ggacatagga ggtatgtcat agaatctgaa
Feature           /change:  aatcagaact tgggtactgt gcgtaagtcc tgtatggagt
Feature           /change:  gtatatcttg gggacagggt ctgttttgct tctgaaatag
Feature           /change:  ccgaattcca tttgcaaaga ctctcttttt ctttctcttt
Feature           /change:  ctctttctgt gtgtgtgtgt atctacaagc tgatctccat
Feature           /change:  aataagcttc acaaggtttg ctgtgtgcct tgagctgctc
Feature           /change:  tgtattgcat attcccatgt ctgaaaattt ctcactactt
Feature           /change:  gtaaaaatac tttaacatct tgctgtgaaa caggaaaagg
Feature           /change:  ttttgtttcc tggttttggc aaaatttgct taatgcatat
Feature           /change:  attagtcttt tggggctgcc taataaagct tctcctttat
Feature           /change:  tatcagagag atactatgta tgtcacttta aataattccc
Feature           /change:  ttagaggcat gttgggaaca atgactttca caattgttct
Feature           /change:  ttgtagcatc cagtgtcttg gttatttatg tgtgatatgg
Feature           /change:  tttggctgtg tccccaccaa atctcaactt gaattgtatc
Feature           /change:  tcccagaatt cccatgtgtt gtgggaggga cccaggggaa
Feature           /change:  ggtaattgaa tcctggggat tggtcttccc tgtgctattc
Feature           /change:  tcgtgatagt gaataagtct catgagatct gatgggttta
Feature           /change:  tcaggggttt ctgcttttgc tccttcctca ttttctcttg
Feature           /change:  ccaccacaat gtaagaagtg cctttcacct cccactatga
Feature           /change:  ctctggggcc tccccagcca tgtggtacta taagtccaat
Feature           /change:  taaacctctt ttcttcccag tcttgggtat gtctttatca
Feature           /change:  gcagtgtgaa aatggactaa tacaatgtga ttgtcacctc
Feature           /change:  cactctttgg tctgctgagg taggtggaaa cctgctttct
Feature           /change:  gaattgttcc ttcctgatat gacagaaaat tttaagattc
Feature           /change:  tatgtgccaa atatagtagg ctattcaaag caggatctag
Feature           /change:  gtctcaatgg ctagaatatt taactaatag aatatcacca
Feature           /change:  tccttccttg ttccctgtga atgctatcag agtatttatt
Feature           /change:  catgtacctg agggtgcctc atcatagtaa gctcagtctt
Feature           /change:  caattttatt catactccca tgcctgcaac aattataatt
Feature           /change:  ttccatcata aaatgaaggg atcagaataa actatttcaa
Feature           /change:  acattcttga ttccttttcc ttttgagctt cagagattgt
Feature           /change:  ttttatgaaa gtgagttttc agctgacttt cttatttagc
Feature           /change:  ctccatacca gggagccaga aggcagtgct tatgaaagcc
Feature           /change:  accatctttc cagtggggga gagaggccag tagctacccc
Feature           /change:  ttttccttct ctatcaggtt tttgctcatc gagattgccc
Feature           /change:  ccaagctagg aattattata agttctccag aattgcatga
Feature           /change:  taattatgaa taaaaagctg acatgggcca ggtgcagtgg
Feature           /change:  ctcatgcctg taatcccaga actttgggag gctgaggcag
Feature           /change:  gtggatcacc tgagatcaag agtttgagac cagcttggcc
Feature           /change:  aacatggtga aaccccatct ctactaaaaa tacaaaactt
Feature           /change:  agctgggcgt ggtggtgcat gcctgtaatt caagctacat
Feature           /change:  gggaggctga ggcaggagaa tcacttgaac ccgggaggca
Feature           /change:  gaggttacag tgagccgaga tagtaccact gcactccagc
Feature           /change:  ctgggcaaca gagcaagacc acctcaaaaa aaaaaaaaaa
Feature           /change:  aaaaaaaaaa gctgacatgg taggtatcta tggaatgggt
Feature           /change:  cacaaatttg agtatgcatt ataatcacct ggagatcatc
Feature           /change:  ctaggcctac cgaatcagaa actctaggtg cccaggcatc
Feature           /change:  tgtaatcttt gaagctctcc agaagattct gtcacctctt
Feature           /change:  gcagaccgag gaccactgag ctaccatcat ctctttgttc
Feature           /change:  ctttgttttc tcttacacaa aactttattg ctcaatgaaa
Feature           /change:  aaaggcttaa gcaatacccc cttccttcct tattggatct
Feature           /change:  ggttttcagt acagattata tgcatgcctg aaaagaaaat
Feature           /change:  tagaaagcag aagcagattt ttggtagttg gttgtcaatt
Feature           /change:  ttcttttgaa ttcttcacct ccatgcaaat tgaagcagga
Feature           /change:  cttattttta gcaacttgat gaatgcaatt taccaaagtt
Feature           /change:  tattacatta tcttttatta caataagaca ggaaggtcag
Feature           /change:  tggaattgtc tgatttttct ttctcattta ccatagttct
Feature           /change:  ctttctagga actcatagta cagaatcaag ctatgggata
Feature           /change:  tataggttat tttgattctc tatttgtgcc cacttctata
Feature           /change:  tttttgtata acttcagtag tgtatacact tttaaccttt
Feature           /change:  ttggagacat tcttaggaat agcagtctct tcgttgactt
Feature           /change:  tctgttgtag ttttcctaat gtttgctccc tggtgaccag
Feature           /change:  gagaccttct atgtcagtgg agacaactca tccaaggctg
Feature           /change:  gctgagccaa gagaggtggg caggaaggcc aggtgaaggc
Feature           /change:  ccccttccct cctttaccac acctcaatag agaatcttta
Feature           /change:  tgtctcctgt accctttctt tttctcttat tagcacatta
Feature           /change:  tggacttgcg ccttcacatg agcttgggcc cttacctgat
Feature           /change:  ttataatttg ctatctatga ctttatggtt gttcaatctt
Feature           /change:  gagaaggaat gactgtccct ggacatcttc caaaaccatt
Feature           /change:  ttctatatga ttgaattgta cttgactctt cttattgtga
Feature           /change:  tgagatgatt tcccccaata gctttttaat ggctgtagga
Feature           /change:  gagcaataca gagcacagga cctgtctagg ataagcagga
Feature           /change:  tacatacaaa tgatccctag tgtcccaggg cgtggtacag
Feature           /change:  tcccttatct acccatttcc ttccattgaa gtgccttgta
Feature           /change:  aggcttggcc aacatgtaag gaaggaaggc atctctcacc
Feature           /change:  tattcttgcc ttgttcatca aaatgcatcc attccatctc
Feature           /change:  atccacttgt tgcatggtag actatattgg gtactaactt
Feature           /change:  aagcagatgg gtacagctca actctacgca aactagctaa
Feature           /change:  tgtgctttcc ccaggtagca taaaatgtta acttgattgc
Feature           /change:  catgcataga cttttaaaag ttgctaagga gttagtcctt
Feature           /change:  taaacgaata gtatttattg ttttatgggg gtttttaaat
Feature           /change:  tatgaaatgt gtgtggacat tataaaaatt ttggaaaata
Feature           /change:  cagaaaagca aaaggaagca atttaaacca tgtataattc
Feature           /change:  cacaactcaa agaaaactat aattaacact ttgatgtgta
Feature           /change:  ttactcaagt ttctgtttca gaatgctgca cattctcttt
Feature           /change:  ctccataact actttttatg cctaacagag tatatatgct
Feature           /change:  tttcatgcca ttagatagcc ttctaaactc tgtgacttat
Feature           /change:  gtagaagcca ggacctcatt attgtgcatt taacttattt
Feature           /change:  ctgaatttct gcaaaaacaa ggtggtgatg aaaatatttt
Feature           /change:  gagcaatgag tttcatacac ttttgcatta tatctttaga
Feature           /change:  ataaatgcac atatgtcaaa acaaatgcac acttgaaaag
Feature           /change:  cttttgatac atattactaa actgacttcc agaaagattc
Feature           /change:  tatcaattac caatttttta aaataatgaa tagactttgt
Feature           /change:  ttgcaaaatc attaagttgc aaaaacaaag acaccacagg
Feature           /change:  agttttaaat tagacttttt tttaatctag aaaaaaaatt
Feature           /change:  taatgtactt gcttagttca gcagaagctg agagaggtct
Feature           /change:  caagaccctg aacaataata ctgattttat tattttatct
Feature           /change:  tattttatgt ttttaagttc cggggtacac gtgcaagatg
Feature           /change:  cgcaggtttg ttacagaggt aaacatgtgc catggtggtt
Feature           /change:  tgctgcacag atcatcccat cacctaggtt ttaagctcag
Feature           /change:  catgcatcag ctcttttccc taatgctctc ccctcccccg
Feature           /change:  cacttccccg acaggcccca ctgtgcatta ttcccctccc
Feature           /change:  tgtgtccagg tgttctcatt gttcacctcc cacttataag
Feature           /change:  tgagaacatg cagtgtttgg ttttctgttc ctgcattagt
Feature           /change:  ttgctgagga taatggcttc cagcttcatc catgtccctg
Feature           /change:  caaagaacat gatctcattc ctctttatgg ctgtatagta
Feature           /change:  cagtctaaca ttgatgggca tttgggttgg ttccgtgtct
Feature           /change:  ttgctattgt gaatagggct gcagtgaaca ttgacatgca
Feature           /change:  tgtgtcttta taatagaatg atttatattc ctttgggtat
Feature           /change:  atacccagta atgggatcgc tggctcaaat ggtgtttcca
Feature           /change:  gttctaaatc tttgaggaat tgccacactg tcttccacaa
Feature           /change:  tggttgaact aattcacatt cccaccaaca gtgtaaaagc
Feature           /change:  attcctattt cttcacaacc accatcagca tctgttgttt
Feature           /change:  cttgacattt taatagtcac cattctgact ggcatgagat
Feature           /change:  ggaattacca gtatgttttg agagttccca gaatccttac
Feature           /change:  ccatttgaaa aagtattgtt tttaaaaaat tcctgctaac
Feature           /change:  tttatgggca agaaaattct cagcagttta atttgcattt
Feature           /change:  ccttgtttaa tacagaagtc ttttgtgact atatttttat
Feature           /change:  acttttgcta aagattattt agtgcattgg ttaagtggtg
Feature           /change:  ctattctaac gcctgagtgt tcacttactg atgaccttga
Feature           /change:  gtaaattcct tgatctccct atgctcacac caactctgat
Feature           /change:  aatggcagta cctactcata gaatctgtat gaagactaaa
Feature           /change:  gagggtatca catgaaagat gcctagaaaa tatcaggcat
Feature           /change:  atataacata cgtttatgtt ctctgtcatt tacatcttct
Feature           /change:  ctgaattgct tcactgtctt tgggtaagta gattttttgg
Feature           /change:  tagcttagaa atatatatat taagtatctt aacctcttgt
Feature           /change:  ctgtcatata ttataatttc tccccagttg gtggtttgtc
Feature           /change:  tttcaatttt gttcaaagtg aggaaacagt tgaatatcaa
Feature           /change:  gaaattcaga ccaggtgaag gcatagtttt ggtccagggt
Feature           /change:  ggatcttttt tctgcctgtc aaccatactg ctaggagaat
Feature           /change:  caccttcccc atccgtgaga aggtctggta ttgattatag
Feature           /change:  ccaccagata tcagaaatgg cactttaagc agcttacatt
Feature           /change:  gttacattaa aaatcaccat catagaataa aacttctgct
Feature           /change:  taatttatgt aaataatgat catggtagat gaaaggccgt
Feature           /change:  ggttaatatt tcaccatttt ccatttacca ccaaatccaa
Feature           /change:  cttgtcagca ttccattagt ggtgatataa aattaattac
Feature           /change:  ttcaacttga aagaagcttt taatttgaga ccaagaaccc
Feature           /change:  tgatagattg cgtaaccatt aagtgttact acttttcccc
Feature           /change:  tctttgctgc aaattgtgta gtagaaaaag aatctttctc
Feature           /change:  atcatgaagt cttgtgtata aacacaagat attccctata
Feature           /change:  ttagcatata tacatgctac taaaaatgaa agtttttcac
Feature           /change:  ttcactgaaa agcaatatga acatagagac tattactttg
Feature           /change:  ccttactaag cagaggaatt accagaacca tccttgtaaa
Feature           /change:  aacatgaaca ttctgcttga gctgccaact tgtttcaaaa
Feature           /change:  agctattaaa agtgggcaaa cattgctgct acatgatgaa
Feature           /change:  tgaatgggag tgtgttgtag tattgctact aggccacgta
Feature           /change:  tgattggaat tttccacata aaagcatttt aaaaagcagt
Feature           /change:  gttatttacg atgcttatca ttagggaatg atattgagaa
Feature           /change:  gaggagtaag gaaacctcaa cttctaaatt ttacacttag
Feature           /change:  atttctgtat tttgttgtca ttttacttca agcatgtttt
Feature           /change:  acttttacaa catcttcaag agaaaaaaat ttaaatcatg
Feature           /change:  atttgcatgg taactgtttt aagagttgtt agtgtgtaca
Feature           /change:  ggaggggatg cttcccagtg ccgaaataga cacaaaatag
Feature           /change:  gcaacattta gatgttggcc ccaaagcctt gtagattatc
Feature           /change:  ctcaattaaa aatacttaag tttgcaagtc tttcttcttc
Feature           /change:  ttttttcttt tttttttttt ctgtgtctgt tttaatttgc
Feature           /change:  aatgattgga aaacataaag caatgaaaag agatggtttc
Feature           /change:  ccaatgcaat ctaaaatttt cacacaccag ggcctgttgt
Feature           /change:  ggggtggggg gaggggggag ggatagcatt aggagatata
Feature           /change:  cctaatgtaa atgatgagtt aatgggtgca gcacaccaac
Feature           /change:  atggcacagg tatacatatg taacaaacct gcacgttgtg
Feature           /change:  cacatgtacc ctagaactta aagtataata aaatatatat
Feature           /change:  aaataaataa ataaataaat aaaattttaa attgctcatt
Feature           /change:  gagttctgcg cggctatgat attgaactgc aggtgcctat
Feature           /change:  aggccttaaa acacaactgt ttcatgttgt tcagtcatct
Feature           /change:  tatttctttc cttgtaagca aaatgtcaga acatttagct
Feature           /change:  cctttagtgc acttattgcc cacaccgagg aatacaaaat
Feature           /change:  tgggactgct gagtaaaatg tttaagtttc aatcccttga
Feature           /change:  aggcaaatat ttgactctca atagagaaat ttaacttcat
Feature           /change:  tatctctact tgcaggcaaa atgaaagacc ggctagcaga
Feature           /change:  acttctggac ttgtccaagc aatatgacca gcagttccca
Feature           /change:  gacggggacg atgagtttga ctcgccccac gaggacatcg
Feature           /change:  tgttcgagac ggaccacatc ctggagtccc tgtaccgaga
Feature           /change:  catccgggac attcaggatg aaaaccagct gctggtggcc
Feature           /change:  gacgtgaagc ggctgggaaa gcagaacgcc cgcttcctca
Feature           /change:  cgtccatgcg gcgcctcagc agcatcaagc gcgacaccaa
Feature           /change:  ctccatcgcc aaggccatca aggcccgggg cgaggtcatc
Feature           /change:  cactgcaagc tgcgcgccat gaaggagctg agcgaggcgg
Feature           /change:  ctgaggccca gcacggcccg cactcggcag tggcgcgcat
Feature           /change:  ttcgcgggcg cagtacaacg cgctcaccct caccttccag
Feature           /change:  cgcgccatgc acgactacaa ccaggccgag atgaagcagc
Feature           /change:  gcgacaactg caagatccgc atccagcgcc agctggagat
Feature           /change:  catgggcaag gaagtctcgg gcgaccagat cgaggacatg
Feature           /change:  ttcgagcagg gtaagtggga cgtgttttcc gagaacttgc
Feature           /change:  tggccgacgt gaagggcgcg cgggccgccc tcaacgagat
Feature           /change:  cgagagccgc caccgcgaac tgctgcgcct ggagagccgc
Feature           /change:  atccgcgacg tacacgagct cttcttgcag atggcggtgc
Feature           /change:  tggtggagaa gcaggccgac accctgaacg tcatcgagct
Feature           /change:  caacgtacaa aagacggtcg actacaccgg ccaggccaag
Feature           /change:  gcgcaggtgc ggaaggccgt gcagtacgag gagaagaacc
Feature           /change:  cctgccggac cctctgctgc ttctgctgtc cctgcctcaa
Feature           /change:  gtagcaggcc ggcccgggcc gccaccgccc atcccagacc
Feature           /change:  atggagcgcg ctgggaagga cgcaccaaag ccgggagctc
Feature           /change:  tgccctgcag ggagttgccc caaccctttc cggaactcag
Feature           /change:  tctttagaaa agaaacgcca ggttcaagaa ttgcaaacca
Feature           /change:  gcctgtgctt ggaaagatgg ttagttgata ccgtccgatg
Feature           /change:  attcttcagt aaagatagat tcccacaaag ttgtgcaatg
Feature           /change:  tcattatatg acaccttgca ctcttaccgt cttgacagaa
Feature           /change:  gccaagtaag gaactgaagt tgtatctgac tgtagggtga
Feature           /change:  atgtctgagg cctgcctcct aataaagact caaggaggaa
Feature           /change:  gtcaattggg catctgctaa tagaatgaac tcatgatgga
Feature           /change:  aacttcagtt catttacttt gtcctgaaaa ttccctggtt
Feature           /change:  ctgttccatt ttgagcgaaa ttggccttgg gaaaaaccac
Feature           /change:  gttcttcctt tccgattctt catccggtct acgctatgca
Feature           /change:  attcctcccc aaatatagat cttatttctg ctcatttccc
Feature           /change:  ctacttatta aaatcacacc aaacacttac tattttctta
Feature           /change:  tctctttcac tttttaaata tctttcacca ggttatattt
Feature           /change:  tggtattatt tttccaaaca tttttaagca ctgaatatcg
Feature           /change:  aacaagcact caaattgaag tatcagtcat gttttgtgta
Feature           /change:  tttttcgctg ataaaaatta tttaacattt atatttttac
Feature           /change:  ttgattacat atgcacatgt atgtaaatgt aaaatactaa
Feature           /change:  tattcactaa tatatgtaca taatgatcaa ttggtttaac
Feature           /change:  ttcttttatg taagtatggt atataaattt caagacgaac
Feature           /change:  acttttctgg ctcttggtat tggtttgctt gttttgagtt
Feature           /change:  tgtttcactc cagtttgccc cttcctagtc cagtttgggt
Feature           /change:  caaacttcat gttaaacaac tctgcattgg ttatggcggt
Feature           /change:  agacatatgg cggtagaaaa tgtatacgga gctagagaca
Feature           /change:  actaacattc ttggaaatac tgcttttgtt ttactgtgga
Feature           /change:  ccattccttc catgcattga aatggagaaa ttcaaagtaa
Feature           /change:  aagaattctg tttttcaagc aagcttaata aacattacat
Feature           /change:  tatacacata tttttataca tttctggctt gaccatttag
Feature           /change:  tttactttct caattattgt taaaattttt ctttttcctt
Feature           /change:  tttttttttt tttttttgag atggagtctc actgtgttgc
Feature           /change:  ccaggctgga gtgcagtggc aggatcttgg ctcattgcaa
Feature           /change:  cctctgtctc ccaggttcga gcgattctcc tgactcagcc
Feature           /change:  tcctgagaag ttgggactct gggcgcgtgc cacaatgtct
Feature           /change:  ggctaatttt ttatgttttt agtaaagacg gtgtttcacc
Feature           /change:  gtgttagcca ggatggtctt gatctcctga cctcgtgatc
Feature           /change:  cgcccgcctc agcctcccat agtgctggga ttacaggtgt
Feature           /change:  gagccaccat gcctggcctt ttttcccccc ttttgagaca
Feature           /change:  gggtctccct ttgtcaccca ggctgaagtg cagtggcata
Feature           /change:  atcatggctt actgcagcct taaactccca ggctcaagtg
Feature           /change:  atcctcccac ctcagcctac aaatagctga gactacagat
Feature           /change:  atgtgccacc atgcccggct aatttttgta ttttctgtag
Feature           /change:  agacagggtt tgccatgtgg cccaggctgg tctcaaactt
Feature           /change:  gtgagcttga gcaatccgcc caccttggcc tcccaaagtg
Feature           /change:  ctgagattac aggcctgagc cactgaccct ggccaaattt
Feature           /change:  tttttctact agctactgag gctgccacat ctggatggaa
Feature           /change:  ctgagtggag ggggaaaaga atgaaaaact caaaagaatt
Feature           /change:  cccatgaggg tgtcttgctt tctctcctga gttacaatac
Feature           /change:  tttagcaaaa tcatgaggct ttagagatat ggtgtagtct
Feature           /change:  gcaaacttct taatgccctt acccacattt accatgtttc
Feature           /change:  ctggccttcc tctgtgtcaa ctcttagctc ttcctaatca
Feature           /change:  ttatttaata catgagtgag tttagtagtg atcatatttc
Feature           /change:  tcaggtcctt tagaagctgg aattttaaaa gaattagaag
Feature           /change:  gaggagtatg tgaattcttt ggagctcact gcctgacttg
Feature           /change:  cttatgacca ggaaaatcta tcccctgtat ctaattttaa
Feature           /change:  tttcatggtt aaatttgaga attgtggaaa ccaagttcca
Feature           /change:  caaggctatt ctcatatttc tcccaatttc tttttcagcc
Feature           /change:  aactccaagg atatgtatca cctttgactt aatttgcttt
Feature           /change:  ctctaaggga aaggggaaaa aatgttcaca tagctccact
Feature           /change:  gcaatgtttt ttataataga ggagagatat tgtaaataga
Feature           /change:  gactgccagc cagtttccac aaaaaaacga agagttcata
Feature           /change:  aatttgacat gtttgaaccc ataaagcatt ttctttgctt
Feature           /change:  ggaaccatta taaaagtaag tgagttttca ggctctatat
Feature           /change:  acattttaat tcctcacgtt ttatattgga gagttcggta
Feature           /change:  cagactgtcc attactgcac caaaagaatg agtgaactgt
Feature           /change:  tacctatagg gaaagaacac ttcttcttcc tgctgtttgg
Feature           /change:  gaaccatctc agtgtggcgt aatggttagg agtacagatt
Feature           /change:  ccagatcctg tttcttagat ttaaatcttg actctgccac
Feature           /change:  atactagctg tctgactgaa ccttggtttt tctgtgcttc
Feature           /change:  agtttcctca tctgtaaaac ggagataaca gtacttacct
Feature           /change:  catagagctg ttgtgaaaag tgatgactga atatgtaaaa
Feature           /change:  gcacctagaa cagtgcctgg cacatgctaa gtgctttgtt
Feature           /change:  cattattgtt gttattatgt aattttctct cagactgaga
Feature           /change:  gcactgttag tgacccaagt aaatttatag tttttaagta
Feature           /change:  cagaggaaaa ataaagccta ttttttgtta acagtcttaa
Feature           /change:  taaataataa aatggaataa agaaaccaag accccatctt
Feature           /change:  ctgtgaatat tagggctttt ttttttttga cagtcataaa
Feature           /change:  gatgttttca ctatggcatt tctatccctg tgtatatcca
Feature           /change:  aacatgtcct gaagaagaaa tgagatgttc caccaaaaac
Feature           /change:  acgtaagcag gaagcagctg ttctgctcag cttggcaggt
Feature           /change:  gttctttcct aattcttccc aagctgtgag tcagaaagtc
Feature           /change:  ctggaaggag ttgtaggaag ttgtagaggc tgggtcactg
Feature           /change:  acctaagaga aggcatcatt tggcccactg cacgtcctgg
Feature           /change:  cctattcacc aaagcccttc ctggctctga ctgccacacc
Feature           /change:  aggcagtggg tgaaatgctg gctttttcct taagaaattg
Feature           /change:  tgttctagtg ccaccaagag atgctgtaga gctggcttta
Feature           /change:  ccaatctcat gatgcttgct tggcaactct gaaaggtgac
Feature           /change:  tttggccaag aagaccttgt ggcaattctg caaattttat
Feature           /change:  acactcatat cttttagggt acaaaatgaa agaacaaatc
Feature           /change:  acaaagaaca atagatcctt caggagctga aggtaagaat
Feature           /change:  cttttatagc tattttaaca tatacagtga ctactttcta
Feature           /change:  ctagccaaat atcaaatttt acaactacca ccaagccaca
Feature           /change:  gattataggt ggtaacaact ccagaaatgt cctaactagg
Feature           /change:  aaaggtgctc atctagtatg catcggtatc caggataata
Feature           /change:  tgagttagaa ttttaaaaat gtcagtcatt caaaaatatt
Feature           /change:  tgaactgtga catcacagaa gtaattttat ggccttttaa
Feature           /change:  ggtaacaact taaaaagaga acagtactct ttttatatca
Feature           /change:  atgcctttac atttatttaa aaacagtcct aatgctttat
Feature           /change:  agttaaatgt catatgcaga tatgttcagg ctctaacata
Feature           /change:  taaagttcct aacttgacag gaaactactg aagattgtgt
Feature           /change:  acagcttaaa aaaaaaaata gggtaactat agtcttgatt
Feature           /change:  tttatgtata aattctatca ttctatattt taccatcaga
Feature           /change:  catatttcta ctcctttctt tgaagtatgc gaagtatctc
Feature           /change:  caactgcagc atgcaactca ttcatttgta atcaagacga
Feature           /change:  tagtttgaaa cacccaattg taatcagagc aacagttgac
Feature           /change:  ttccttttga tagcggagtt gaaaatcatt gcaattaata
Feature           /change:  aaatggggct attagaaatg gaaaacgaat aggatctaga
Feature           /change:  atgtaacttc atcatataaa tgatgagtgt ctttgttatc
Feature           /change:  aacacgttat taagaatggg caagatgtcc ttatatacta
Feature           /change:  gaagcttttg taaagtcatg tgtctattga taataaagat
Feature           /change:  tttcggaact gatgttctga gtgagactac aaaggatgct
Feature           /change:  ttaaaacgag tgatatctgg ccgggcatgg tggttcccac
Feature           /change:  ctatactccc agcactttcg gaggccaagg caggcagatc
Feature           /change:  acttgaggcc aagagttcga gaccagcctg gccaacatgg
Feature           /change:  tgaaacccct tctctactga aaatacaaaa attagctggg
Feature           /change:  catggcagtg catgcctgta atcccagcta ccctggaggc
Feature           /change:  tgaagcacga ggatcacttg aaccaaggag gcagaggttg
Feature           /change:  cagtgaactg agatcgcacc actgcactct agccttggca
Feature           /change:  acagagtgag accctgtctc aaaaaacaag caaacaacaa
Feature           /change:  caataaaacc agtgatgccc tgcaaaatga ggattgagag
Feature           /change:  acaagtcccc aacactatat tttttaattc ctgatgtttc
Feature           /change:  tttttaagtt acattttata ttctatttga agcatctata
Feature           /change:  gacacttctt ggacctcttc tatttttctt agtctatatt
Feature           /change:  tctatatttt catggtccta tagccaactc tttagacata
Feature           /change:  tccactcttc tgtatctcag catcccataa tgtttgatag
Feature           /change:  agggtaaaaa taacagagta tacacacaca cacacacaca
Feature           /change:  cacacacaca cacacacaga atctaccatc gtccccatcc
Feature           /change:  cctgctcctt ctgtctatct taacttgcaa atggcaggat
Feature           /change:  caatcaactg ccacctgccc aggtcagaca attatcctct
Feature           /change:  cttgcttcca ttacttcagc agcttttaat tggcctctgg
Feature           /change:  cctctagtct tatcctctcc agtctaatct ctgtacaatg
Feature           /change:  ctatagtaca gccacagtgc ctttttgttg ttgttgtcat
Feature           /change:  tacgctgttg tttttaattg cagtattata tacatgactt
Feature           /change:  aaacttacca tcctaaccat tcttaaatat acatttcatg
Feature           /change:  tattggttgg ttctcacatt gctataaaga actatctgag
Feature           /change:  actgggtagt ttataaagag aaaatgttta attgactcac
Feature           /change:  agttccatag gctgtacagg aggcatggcc agggaggcct
Feature           /change:  caggaaactt acaatcatgg cagaaggtga agtggaagca
Feature           /change:  agtacatctt cacatggtga caggaaagag agagagagag
Feature           /change:  agagagagag agagacagag caaagggaga agtgccacac
Feature           /change:  acttttaaac catcagatct catgagaact cactcagtgt
Feature           /change:  cacaagaaca gcaaggggga aatctgctcc catgatccaa
Feature           /change:  tcatctccca gcagctccct tccccaacat tgggaattat
Feature           /change:  aattcaacat gagatttggg tggggacaca gagccaaact
Feature           /change:  atatcagttc ccatactgct aagtacactc atattgttgt
Feature           /change:  gcaaccagtc tccaggattc ttttcatctt tcaaaactga
Feature           /change:  actctatact caataaacaa aaactgctca tccctccagc
Feature           /change:  ccctggcaac caccattctg ctttctatct ctatgagctt
Feature           /change:  gactgctcta gatactgcat tgaactggaa taatatagta
Feature           /change:  tttgtcctgt cgtgtctggc ttatttcact tagcattatg
Feature           /change:  tcctcaagct tcatccatgt tgtagtgcgt gtcagatttt
Feature           /change:  aaagctcagt aatatgccat cgtatttata gagtacattt
Feature           /change:  tgtttagtca ttcacctgtc aatggacaca ggttgctccc
Feature           /change:  actttttggc tgctgtgaat agtgccgttc aactgcttaa
Feature           /change:  aactctgtaa tggctgctga ttgctgttgg gataaaatct
Feature           /change:  catctcctta gtgaggttct tcaaggccct gaaggagcca
Feature           /change:  ggccccgctt actttcagct tcatccctga cacctttcat
Feature           /change:  tgcttgcttg ctttccttcc ttctttcttt ctttctctct
Feature           /change:  ctttttcttt ctttctttta tttctttttc tttctttctt
Feature           /change:  ttctttcttc tttctctttc tttcttcttt ctttctttta
Feature           /change:  tttcttctct ctctctcttt tagagagagg gtcttgccta
Feature           /change:  ggccggagtg cagtggcaca attatagctc actgcagcct
Feature           /change:  caaattccca ggttcaagcg atcttctcac ctcagcctcc
Feature           /change:  tgagtcgctg ggaccacaga cacgagacac caccctggct
Feature           /change:  acttcaaagc actgcaccca cccactcagt tccattgttg
Feature           /change:  cgtaggagct ccgtgaagtg catatttaag gactgcatcg
Feature           /change:  cccccatctt cacggtgtta tgtgtgcttc tgttactaaa
Feature           /change:  ctgctttttt atttttaagg acaaccaata acatcttact
Feature           /change:  tgttttggga tcttagcact ttgcatagta tcttttatag
Feature           /change:  gcatttgggt atttgtgttc tacatgcaga aatagagata
Feature           /change:  ttcagaattt gttttctgct atgagtgact ttttgtatag
Feature           /change:  ctttttgaag atgcatattt tacagcataa agcacggtat
Feature           /change:  ctagtttctc ctcccggagg atctgtgtcg ggtgctgagt
Feature           /change:  gaggccagga tgcggttggg ggcgcagtgt cctgagaagg
Feature           /change:  ggggtgggac ttggtgaggg gaggggacat gggactggag
Feature           /change:  aaagactgct tgggaagaag cagatcatgc aggagaacgg
Feature           /change:  tcagtctgaa aaggtgagtg gagagagaat gaagttctga
Feature           /change:  gtcacgggca ctgaagccag cagaactggg agcaaacaga
Feature           /change:  ggctgggatt gggtgctgtg tggcagagcc tggaagaaat
Feature           /change:  agcttagtca aggtacagac tcaatttgga tgcaaagaaa
Feature           /change:  gttgtaaaac tacattttat ctggaagtga ttttcttttt
Feature           /change:  ctttttattc ttcaaagcat gtaaaacaaa gttttctttt
Feature           /change:  tttttaattt tggacaaaat gtgttggctt gagtttcagc
Feature           /change:  tggacatatt tccatctaac atggcatcca gtagggtaat
Feature           /change:  ttgtgcaaag tacttagctc cctgctccta gtcacacagg
Feature           /change:  gctgtgtggc agctttcggc ttcagtccta aaacgccctc
Feature           /change:  agccactgaa gtcgccatgg tatggtaatg gtctgagatg
Feature           /change:  cctcagtctg tgcctctgaa tatgtcaggg aatcccacca
Feature           /change:  ccccccaccc cacacacatc cagactgctt atgaatccat
Feature           /change:  aatacttact caatacaaaa atgtctaaca gcctgtggat
Feature           /change:  tgtgcagaac agtaacagca agggtcttct tttcctacaa
Feature           /change:  gcgttgaaga ccaaggagag aatggaggac cctaaactgc
Feature           /change:  ccttgcttgg agctgcaagt tctctccctg ctgaagctga
Feature           /change:  ccctgcaggt cgactgctgc ttgggcctga agtgcctctc
Feature           /change:  agccaccagc agccaactct ttgaaaacat ggatttgggc
Feature           /change:  caggtgtggt ggctcacacc tgtaatccca acactttggg
Feature           /change:  aggccaaggc aggaggatca cctgagggca ggtgtttgag
Feature           /change:  accagcctgg ccaacatggt gaaaccccat ctctactaaa
Feature           /change:  aatacaaaaa ttagctcggt gtggtggcgc atgcctgtaa
Feature           /change:  tcccagctac ttgagaggct gaggcaggag aatcccttga
Feature           /change:  acctgggagg tggaggttgt tacagtgagc caagatcgtg
Feature           /change:  ccactgtcct ccagcctggc ctgggcaaca gagtgagaca
Feature           /change:  ctgtctcaaa aaaaaaaaaa aattaagaaa aaaaaataaa
Feature           /change:  caaaaaacaa aacaaacaaa aaaacacatg attgtgaacc
Feature           /change:  aaatcaagca aagaatctcc aggggggtag tgcctataaa
Feature           /change:  aggaatgtta cccccagata aaaacaaact atttagattc
Feature           /change:  tacatgacag aggaatttct cttgtgggta ggaatgttta
Feature           /change:  actaattcat tccttggctc tgctatgtgg tttaccctgg
Feature           /change:  tctcatgcac ccttagaagg gcatagatga ggtaacatgg
Feature           /change:  tttcttttca taatcttcat ccacgccttg tcatctggtt
Feature           /change:  tatggaagaa acctgtcaaa caagaaacgt tacctagtgg
Feature           /change:  caagatgtta ggacatgcag ttactaggag aaagtaaacg
Feature           /change:  gcctggaaga tgaaagacat ggccattttt ttaaggctgc
Feature           /change:  aactccacag gaggggtagc ttctcctgtt
Feature           /genomic_region: intron; 1
Feature         rna; 2
Feature           /dnalink: 1
Feature           /aalink: 3
Feature           /name: unknown
Feature           /inexloc: -9735
Feature         aa; 3
Feature           /rnalink: 2
Feature           /name: unknown
FeatureHeader   allele; 2
Feature         dna; 4
Feature           /rnalink: 5
Feature           /name: deletion
Feature           /loc: IDRefSeq: D0083: 27357..46546
Feature           /change: -tacttacatg gaaaaccctc atgcattgat gatgttggat
Feature           /change:  aactcagata tttccgtacc ttgtgtaaaa gatatcagcc
Feature           /change:  atatataaga atattttttc tgggagaatt taacaggagt
Feature           /change:  aaccaggcaa tgagactaga ataagtggcc caaaggacac
Feature           /change:  tgtttacaag aaagaggaac agataaagga atgtaaaaat
Feature           /change:  tcttaactgg tgttacgagt tggaaaagaa aaggtcattg
Feature           /change:  atgattctgg aaactccatg gatttctccc tttcaaagat
Feature           /change:  acttcatgga atagttacaa aatataaagg aattacttaa
Feature           /change:  aggcatatat gttttccaac tggactcaaa atctattccc
Feature           /change:  catcattttt taaacataga tctttgctgt attttccagg
Feature           /change:  caaagttttg cttcacattc tagggccaaa gggaaatcag
Feature           /change:  atgtaagagt tacaacaact gttttagttt gtaaatacta
Feature           /change:  atagagatac aagtggaaaa atttgcacag atgacttgag
Feature           /change:  ccttgaggcc ttgacccttg agtgctcctg tctttacttt
Feature           /change:  ctcccttagc tcatctactg gctgggagcg gtggctcacg
Feature           /change:  cctgtaatcc cagcactttg ggaggctgag gcaggcggat
Feature           /change:  cacaaggtca ggagtttgag accaacctgg ccaatatagt
Feature           /change:  gaaaccccat ctctactaaa aacacacaaa aaattagccg
Feature           /change:  ggtgtggtgg tgcacacctg taatcccagc tactcaggag
Feature           /change:  gctgaggcag gagaattgct tgaacccggg aggcaaaggt
Feature           /change:  tgcggtgagc caagattgca ccactgcact ccagcctggg
Feature           /change:  tgacagaggg agactccgtc tcaaaaaaaa gaagaaagaa
Feature           /change:  agctcatcta ctgtcctttc ctgctgtggc ttctatgcac
Feature           /change:  ctgactgtaa aatttacatc tccaagtgtc tgtattctgt
Feature           /change:  tatttcagag agttaataat tttatggatt ttttttaaag
Feature           /change:  ttgtggtgac ttactccctg tttttaggac tgtaacaact
Feature           /change:  gaagtgttgc aatgttgggg aaactctgat atgaagaaat
Feature           /change:  ttgtgtggga aagaaagtag tgattctaat ggtgacagta
Feature           /change:  tttccatgtg ttaatccagt tctaagaatt agatgctaat
Feature           /change:  aattgttcct aatagaaaag ctcaattagg gaatacgttt
Feature           /change:  cctattagac taacgatttt aaaagaagcc ttcttgtggg
Feature           /change:  gagtttagga aaaagaagct agtgtagctt tgtggattac
Feature           /change:  ggatggattc tcaagtagtc acacttttgg gatttatatc
Feature           /change:  tcaactccat aactgtatga ctttaggcaa actgcttaaa
Feature           /change:  ctcattaggc ctcaaacctg tagactgggg atgatgataa
Feature           /change:  tacctcataa ggaataaatg ggttaatacc tgcccattgc
Feature           /change:  tgagtaccgc atttggcatt ttacaaatgc ttaataaatg
Feature           /change:  ttcactgtag agcagaatgt atgaaaccta cacaggagta
Feature           /change:  gctgctttga tttcccgtgc atttctacag aaagcatctg
Feature           /change:  aaagcatatt gctaaaagtg aaatcccagc tacccactgg
Feature           /change:  ctgtttatca actgtgcata tcaaactgcc tttttctctt
Feature           /change:  cacacactgg cagaaaattc tgattgagga aactgaaaag
Feature           /change:  cgaattatgt cagagggcat caaatgagta aagtgattga
Feature           /change:  aaagtagagg ctgtctcctc cagcagtggt ttgaataact
Feature           /change:  cctacctgct ttctgcttta gagcaaagag aaaacaagag
Feature           /change:  acatttaaaa attatttctt ctagcctcag acttttatcg
Feature           /change:  ttataaacca tttcaattaa tactcttcag cctttcaaat
Feature           /change:  tttgctttga atgagcccta agacaatatt aaatgcgttc
Feature           /change:  ttgcccaatg cactttaaga tacgatacaa gctttttttt
Feature           /change:  ttttaaatta acttcggagc agcaagaaaa ttagagctat
Feature           /change:  tcattaggaa ctttttagtt ttaacctgta atgttttgat
Feature           /change:  gttcaaagaa tagtgtttcc ctctgtatta gtctgttttc
Feature           /change:  atgctgctga taaagacata tctgagactg ggcaatttac
Feature           /change:  aaaagaaaga ggtttaatgg acttacagtt ccacgtggct
Feature           /change:  ggggagaact tacaatcatg gtgaggcaat ggtgaggcat
Feature           /change:  ggtgaatgca aggaggggca agtcacatct tatgtggatg
Feature           /change:  gtggcagaca aaaagagaat gaagaggatg caaaagcaga
Feature           /change:  aacctctaat aaaaccatca gatctcatga cacttattca
Feature           /change:  ctaccaccag aacagcatgg gggaaaccgc ccccatgatt
Feature           /change:  cagttatctc ccaccggatc cctcgcacaa cgtgtgggaa
Feature           /change:  ttatgggagt accattcaag atgagatttg ggtggggaca
Feature           /change:  tagagccaaa ccatatcacc ctcttagatg tgtcatttta
Feature           /change:  aaaatcaaga aacagaacac tggttttact cagttgagtg
Feature           /change:  aaattattgt ttatgaacct gttggggaaa gtccatttgt
Feature           /change:  tgttctttaa gggctgtgtt actatggggt atgctagaaa
Feature           /change:  ggaactgcta aattacagtg acactctacc tgtggaattt
Feature           /change:  ctaggtgcct ctggtagcgg ggatgtgtgg gcaggaggga
Feature           /change:  ctggatgagg tggttgagaa aggggtacac agggtgaccc
Feature           /change:  catggggctg tgcaggttgt gatctcacca cagatgagag
Feature           /change:  agactggcaa tccaaccatg ctcagctcac caggatgcat
Feature           /change:  gcccttgggc agggctttat ccacccagag aaagggccct
Feature           /change:  ttcctagctt tcacaaagat actatataag cccaacacaa
Feature           /change:  aacctcatta aggcacccta tagaccaata gtggaccttc
Feature           /change:  tgatttgtaa taatcacttt aatcatatgt ttacaattgg
Feature           /change:  tataaaatta ggacatagga ggtatgtcat agaatctgaa
Feature           /change:  aatcagaact tgggtactgt gcgtaagtcc tgtatggagt
Feature           /change:  gtatatcttg gggacagggt ctgttttgct tctgaaatag
Feature           /change:  ccgaattcca tttgcaaaga ctctcttttt ctttctcttt
Feature           /change:  ctctttctgt gtgtgtgtgt atctacaagc tgatctccat
Feature           /change:  aataagcttc acaaggtttg ctgtgtgcct tgagctgctc
Feature           /change:  tgtattgcat attcccatgt ctgaaaattt ctcactactt
Feature           /change:  gtaaaaatac tttaacatct tgctgtgaaa caggaaaagg
Feature           /change:  ttttgtttcc tggttttggc aaaatttgct taatgcatat
Feature           /change:  attagtcttt tggggctgcc taataaagct tctcctttat
Feature           /change:  tatcagagag atactatgta tgtcacttta aataattccc
Feature           /change:  ttagaggcat gttgggaaca atgactttca caattgttct
Feature           /change:  ttgtagcatc cagtgtcttg gttatttatg tgtgatatgg
Feature           /change:  tttggctgtg tccccaccaa atctcaactt gaattgtatc
Feature           /change:  tcccagaatt cccatgtgtt gtgggaggga cccaggggaa
Feature           /change:  ggtaattgaa tcctggggat tggtcttccc tgtgctattc
Feature           /change:  tcgtgatagt gaataagtct catgagatct gatgggttta
Feature           /change:  tcaggggttt ctgcttttgc tccttcctca ttttctcttg
Feature           /change:  ccaccacaat gtaagaagtg cctttcacct cccactatga
Feature           /change:  ctctggggcc tccccagcca tgtggtacta taagtccaat
Feature           /change:  taaacctctt ttcttcccag tcttgggtat gtctttatca
Feature           /change:  gcagtgtgaa aatggactaa tacaatgtga ttgtcacctc
Feature           /change:  cactctttgg tctgctgagg taggtggaaa cctgctttct
Feature           /change:  gaattgttcc ttcctgatat gacagaaaat tttaagattc
Feature           /change:  tatgtgccaa atatagtagg ctattcaaag caggatctag
Feature           /change:  gtctcaatgg ctagaatatt taactaatag aatatcacca
Feature           /change:  tccttccttg ttccctgtga atgctatcag agtatttatt
Feature           /change:  catgtacctg agggtgcctc atcatagtaa gctcagtctt
Feature           /change:  caattttatt catactccca tgcctgcaac aattataatt
Feature           /change:  ttccatcata aaatgaaggg atcagaataa actatttcaa
Feature           /change:  acattcttga ttccttttcc ttttgagctt cagagattgt
Feature           /change:  ttttatgaaa gtgagttttc agctgacttt cttatttagc
Feature           /change:  ctccatacca gggagccaga aggcagtgct tatgaaagcc
Feature           /change:  accatctttc cagtggggga gagaggccag tagctacccc
Feature           /change:  ttttccttct ctatcaggtt tttgctcatc gagattgccc
Feature           /change:  ccaagctagg aattattata agttctccag aattgcatga
Feature           /change:  taattatgaa taaaaagctg acatgggcca ggtgcagtgg
Feature           /change:  ctcatgcctg taatcccaga actttgggag gctgaggcag
Feature           /change:  gtggatcacc tgagatcaag agtttgagac cagcttggcc
Feature           /change:  aacatggtga aaccccatct ctactaaaaa tacaaaactt
Feature           /change:  agctgggcgt ggtggtgcat gcctgtaatt caagctacat
Feature           /change:  gggaggctga ggcaggagaa tcacttgaac ccgggaggca
Feature           /change:  gaggttacag tgagccgaga tagtaccact gcactccagc
Feature           /change:  ctgggcaaca gagcaagacc acctcaaaaa aaaaaaaaaa
Feature           /change:  aaaaaaaaaa gctgacatgg taggtatcta tggaatgggt
Feature           /change:  cacaaatttg agtatgcatt ataatcacct ggagatcatc
Feature           /change:  ctaggcctac cgaatcagaa actctaggtg cccaggcatc
Feature           /change:  tgtaatcttt gaagctctcc agaagattct gtcacctctt
Feature           /change:  gcagaccgag gaccactgag ctaccatcat ctctttgttc
Feature           /change:  ctttgttttc tcttacacaa aactttattg ctcaatgaaa
Feature           /change:  aaaggcttaa gcaatacccc cttccttcct tattggatct
Feature           /change:  ggttttcagt acagattata tgcatgcctg aaaagaaaat
Feature           /change:  tagaaagcag aagcagattt ttggtagttg gttgtcaatt
Feature           /change:  ttcttttgaa ttcttcacct ccatgcaaat tgaagcagga
Feature           /change:  cttattttta gcaacttgat gaatgcaatt taccaaagtt
Feature           /change:  tattacatta tcttttatta caataagaca ggaaggtcag
Feature           /change:  tggaattgtc tgatttttct ttctcattta ccatagttct
Feature           /change:  ctttctagga actcatagta cagaatcaag ctatgggata
Feature           /change:  tataggttat tttgattctc tatttgtgcc cacttctata
Feature           /change:  tttttgtata acttcagtag tgtatacact tttaaccttt
Feature           /change:  ttggagacat tcttaggaat agcagtctct tcgttgactt
Feature           /change:  tctgttgtag ttttcctaat gtttgctccc tggtgaccag
Feature           /change:  gagaccttct atgtcagtgg agacaactca tccaaggctg
Feature           /change:  gctgagccaa gagaggtggg caggaaggcc aggtgaaggc
Feature           /change:  ccccttccct cctttaccac acctcaatag agaatcttta
Feature           /change:  tgtctcctgt accctttctt tttctcttat tagcacatta
Feature           /change:  tggacttgcg ccttcacatg agcttgggcc cttacctgat
Feature           /change:  ttataatttg ctatctatga ctttatggtt gttcaatctt
Feature           /change:  gagaaggaat gactgtccct ggacatcttc caaaaccatt
Feature           /change:  ttctatatga ttgaattgta cttgactctt cttattgtga
Feature           /change:  tgagatgatt tcccccaata gctttttaat ggctgtagga
Feature           /change:  gagcaataca gagcacagga cctgtctagg ataagcagga
Feature           /change:  tacatacaaa tgatccctag tgtcccaggg cgtggtacag
Feature           /change:  tcccttatct acccatttcc ttccattgaa gtgccttgta
Feature           /change:  aggcttggcc aacatgtaag gaaggaaggc atctctcacc
Feature           /change:  tattcttgcc ttgttcatca aaatgcatcc attccatctc
Feature           /change:  atccacttgt tgcatggtag actatattgg gtactaactt
Feature           /change:  aagcagatgg gtacagctca actctacgca aactagctaa
Feature           /change:  tgtgctttcc ccaggtagca taaaatgtta acttgattgc
Feature           /change:  catgcataga cttttaaaag ttgctaagga gttagtcctt
Feature           /change:  taaacgaata gtatttattg ttttatgggg gtttttaaat
Feature           /change:  tatgaaatgt gtgtggacat tataaaaatt ttggaaaata
Feature           /change:  cagaaaagca aaaggaagca atttaaacca tgtataattc
Feature           /change:  cacaactcaa agaaaactat aattaacact ttgatgtgta
Feature           /change:  ttactcaagt ttctgtttca gaatgctgca cattctcttt
Feature           /change:  ctccataact actttttatg cctaacagag tatatatgct
Feature           /change:  tttcatgcca ttagatagcc ttctaaactc tgtgacttat
Feature           /change:  gtagaagcca ggacctcatt attgtgcatt taacttattt
Feature           /change:  ctgaatttct gcaaaaacaa ggtggtgatg aaaatatttt
Feature           /change:  gagcaatgag tttcatacac ttttgcatta tatctttaga
Feature           /change:  ataaatgcac atatgtcaaa acaaatgcac acttgaaaag
Feature           /change:  cttttgatac atattactaa actgacttcc agaaagattc
Feature           /change:  tatcaattac caatttttta aaataatgaa tagactttgt
Feature           /change:  ttgcaaaatc attaagttgc aaaaacaaag acaccacagg
Feature           /change:  agttttaaat tagacttttt tttaatctag aaaaaaaatt
Feature           /change:  taatgtactt gcttagttca gcagaagctg agagaggtct
Feature           /change:  caagaccctg aacaataata ctgattttat tattttatct
Feature           /change:  tattttatgt ttttaagttc cggggtacac gtgcaagatg
Feature           /change:  cgcaggtttg ttacagaggt aaacatgtgc catggtggtt
Feature           /change:  tgctgcacag atcatcccat cacctaggtt ttaagctcag
Feature           /change:  catgcatcag ctcttttccc taatgctctc ccctcccccg
Feature           /change:  cacttccccg acaggcccca ctgtgcatta ttcccctccc
Feature           /change:  tgtgtccagg tgttctcatt gttcacctcc cacttataag
Feature           /change:  tgagaacatg cagtgtttgg ttttctgttc ctgcattagt
Feature           /change:  ttgctgagga taatggcttc cagcttcatc catgtccctg
Feature           /change:  caaagaacat gatctcattc ctctttatgg ctgtatagta
Feature           /change:  cagtctaaca ttgatgggca tttgggttgg ttccgtgtct
Feature           /change:  ttgctattgt gaatagggct gcagtgaaca ttgacatgca
Feature           /change:  tgtgtcttta taatagaatg atttatattc ctttgggtat
Feature           /change:  atacccagta atgggatcgc tggctcaaat ggtgtttcca
Feature           /change:  gttctaaatc tttgaggaat tgccacactg tcttccacaa
Feature           /change:  tggttgaact aattcacatt cccaccaaca gtgtaaaagc
Feature           /change:  attcctattt cttcacaacc accatcagca tctgttgttt
Feature           /change:  cttgacattt taatagtcac cattctgact ggcatgagat
Feature           /change:  ggaattacca gtatgttttg agagttccca gaatccttac
Feature           /change:  ccatttgaaa aagtattgtt tttaaaaaat tcctgctaac
Feature           /change:  tttatgggca agaaaattct cagcagttta atttgcattt
Feature           /change:  ccttgtttaa tacagaagtc ttttgtgact atatttttat
Feature           /change:  acttttgcta aagattattt agtgcattgg ttaagtggtg
Feature           /change:  ctattctaac gcctgagtgt tcacttactg atgaccttga
Feature           /change:  gtaaattcct tgatctccct atgctcacac caactctgat
Feature           /change:  aatggcagta cctactcata gaatctgtat gaagactaaa
Feature           /change:  gagggtatca catgaaagat gcctagaaaa tatcaggcat
Feature           /change:  atataacata cgtttatgtt ctctgtcatt tacatcttct
Feature           /change:  ctgaattgct tcactgtctt tgggtaagta gattttttgg
Feature           /change:  tagcttagaa atatatatat taagtatctt aacctcttgt
Feature           /change:  ctgtcatata ttataatttc tccccagttg gtggtttgtc
Feature           /change:  tttcaatttt gttcaaagtg aggaaacagt tgaatatcaa
Feature           /change:  gaaattcaga ccaggtgaag gcatagtttt ggtccagggt
Feature           /change:  ggatcttttt tctgcctgtc aaccatactg ctaggagaat
Feature           /change:  caccttcccc atccgtgaga aggtctggta ttgattatag
Feature           /change:  ccaccagata tcagaaatgg cactttaagc agcttacatt
Feature           /change:  gttacattaa aaatcaccat catagaataa aacttctgct
Feature           /change:  taatttatgt aaataatgat catggtagat gaaaggccgt
Feature           /change:  ggttaatatt tcaccatttt ccatttacca ccaaatccaa
Feature           /change:  cttgtcagca ttccattagt ggtgatataa aattaattac
Feature           /change:  ttcaacttga aagaagcttt taatttgaga ccaagaaccc
Feature           /change:  tgatagattg cgtaaccatt aagtgttact acttttcccc
Feature           /change:  tctttgctgc aaattgtgta gtagaaaaag aatctttctc
Feature           /change:  atcatgaagt cttgtgtata aacacaagat attccctata
Feature           /change:  ttagcatata tacatgctac taaaaatgaa agtttttcac
Feature           /change:  ttcactgaaa agcaatatga acatagagac tattactttg
Feature           /change:  ccttactaag cagaggaatt accagaacca tccttgtaaa
Feature           /change:  aacatgaaca ttctgcttga gctgccaact tgtttcaaaa
Feature           /change:  agctattaaa agtgggcaaa cattgctgct acatgatgaa
Feature           /change:  tgaatgggag tgtgttgtag tattgctact aggccacgta
Feature           /change:  tgattggaat tttccacata aaagcatttt aaaaagcagt
Feature           /change:  gttatttacg atgcttatca ttagggaatg atattgagaa
Feature           /change:  gaggagtaag gaaacctcaa cttctaaatt ttacacttag
Feature           /change:  atttctgtat tttgttgtca ttttacttca agcatgtttt
Feature           /change:  acttttacaa catcttcaag agaaaaaaat ttaaatcatg
Feature           /change:  atttgcatgg taactgtttt aagagttgtt agtgtgtaca
Feature           /change:  ggaggggatg cttcccagtg ccgaaataga cacaaaatag
Feature           /change:  gcaacattta gatgttggcc ccaaagcctt gtagattatc
Feature           /change:  ctcaattaaa aatacttaag tttgcaagtc tttcttcttc
Feature           /change:  ttttttcttt tttttttttt ctgtgtctgt tttaatttgc
Feature           /change:  aatgattgga aaacataaag caatgaaaag agatggtttc
Feature           /change:  ccaatgcaat ctaaaatttt cacacaccag ggcctgttgt
Feature           /change:  ggggtggggg gaggggggag ggatagcatt aggagatata
Feature           /change:  cctaatgtaa atgatgagtt aatgggtgca gcacaccaac
Feature           /change:  atggcacagg tatacatatg taacaaacct gcacgttgtg
Feature           /change:  cacatgtacc ctagaactta aagtataata aaatatatat
Feature           /change:  aaataaataa ataaataaat aaaattttaa attgctcatt
Feature           /change:  gagttctgcg cggctatgat attgaactgc aggtgcctat
Feature           /change:  aggccttaaa acacaactgt ttcatgttgt tcagtcatct
Feature           /change:  tatttctttc cttgtaagca aaatgtcaga acatttagct
Feature           /change:  cctttagtgc acttattgcc cacaccgagg aatacaaaat
Feature           /change:  tgggactgct gagtaaaatg tttaagtttc aatcccttga
Feature           /change:  aggcaaatat ttgactctca atagagaaat ttaacttcat
Feature           /change:  tatctctact tgcaggcaaa atgaaagacc ggctagcaga
Feature           /change:  acttctggac ttgtccaagc aatatgacca gcagttccca
Feature           /change:  gacggggacg atgagtttga ctcgccccac gaggacatcg
Feature           /change:  tgttcgagac ggaccacatc ctggagtccc tgtaccgaga
Feature           /change:  catccgggac attcaggatg aaaaccagct gctggtggcc
Feature           /change:  gacgtgaagc ggctgggaaa gcagaacgcc cgcttcctca
Feature           /change:  cgtccatgcg gcgcctcagc agcatcaagc gcgacaccaa
Feature           /change:  ctccatcgcc aaggccatca aggcccgggg cgaggtcatc
Feature           /change:  cactgcaagc tgcgcgccat gaaggagctg agcgaggcgg
Feature           /change:  ctgaggccca gcacggcccg cactcggcag tggcgcgcat
Feature           /change:  ttcgcgggcg cagtacaacg cgctcaccct caccttccag
Feature           /change:  cgcgccatgc acgactacaa ccaggccgag atgaagcagc
Feature           /change:  gcgacaactg caagatccgc atccagcgcc agctggagat
Feature           /change:  catgggcaag gaagtctcgg gcgaccagat cgaggacatg
Feature           /change:  ttcgagcagg gtaagtggga cgtgttttcc gagaacttgc
Feature           /change:  tggccgacgt gaagggcgcg cgggccgccc tcaacgagat
Feature           /change:  cgagagccgc caccgcgaac tgctgcgcct ggagagccgc
Feature           /change:  atccgcgacg tacacgagct cttcttgcag atggcggtgc
Feature           /change:  tggtggagaa gcaggccgac accctgaacg tcatcgagct
Feature           /change:  caacgtacaa aagacggtcg actacaccgg ccaggccaag
Feature           /change:  gcgcaggtgc ggaaggccgt gcagtacgag gagaagaacc
Feature           /change:  cctgccggac cctctgctgc ttctgctgtc cctgcctcaa
Feature           /change:  gtagcaggcc ggcccgggcc gccaccgccc atcccagacc
Feature           /change:  atggagcgcg ctgggaagga cgcaccaaag ccgggagctc
Feature           /change:  tgccctgcag ggagttgccc caaccctttc cggaactcag
Feature           /change:  tctttagaaa agaaacgcca ggttcaagaa ttgcaaacca
Feature           /change:  gcctgtgctt ggaaagatgg ttagttgata ccgtccgatg
Feature           /change:  attcttcagt aaagatagat tcccacaaag ttgtgcaatg
Feature           /change:  tcattatatg acaccttgca ctcttaccgt cttgacagaa
Feature           /change:  gccaagtaag gaactgaagt tgtatctgac tgtagggtga
Feature           /change:  atgtctgagg cctgcctcct aataaagact caaggaggaa
Feature           /change:  gtcaattggg catctgctaa tagaatgaac tcatgatgga
Feature           /change:  aacttcagtt catttacttt gtcctgaaaa ttccctggtt
Feature           /change:  ctgttccatt ttgagcgaaa ttggccttgg gaaaaaccac
Feature           /change:  gttcttcctt tccgattctt catccggtct acgctatgca
Feature           /change:  attcctcccc aaatatagat cttatttctg ctcatttccc
Feature           /change:  ctacttatta aaatcacacc aaacacttac tattttctta
Feature           /change:  tctctttcac tttttaaata tctttcacca ggttatattt
Feature           /change:  tggtattatt tttccaaaca tttttaagca ctgaatatcg
Feature           /change:  aacaagcact caaattgaag tatcagtcat gttttgtgta
Feature           /change:  tttttcgctg ataaaaatta tttaacattt atatttttac
Feature           /change:  ttgattacat atgcacatgt atgtaaatgt aaaatactaa
Feature           /change:  tattcactaa tatatgtaca taatgatcaa ttggtttaac
Feature           /change:  ttcttttatg taagtatggt atataaattt caagacgaac
Feature           /change:  acttttctgg ctcttggtat tggtttgctt gttttgagtt
Feature           /change:  tgtttcactc cagtttgccc cttcctagtc cagtttgggt
Feature           /change:  caaacttcat gttaaacaac tctgcattgg ttatggcggt
Feature           /change:  agacatatgg cggtagaaaa tgtatacgga gctagagaca
Feature           /change:  actaacattc ttggaaatac tgcttttgtt ttactgtgga
Feature           /change:  ccattccttc catgcattga aatggagaaa ttcaaagtaa
Feature           /change:  aagaattctg tttttcaagc aagcttaata aacattacat
Feature           /change:  tatacacata tttttataca tttctggctt gaccatttag
Feature           /change:  tttactttct caattattgt taaaattttt ctttttcctt
Feature           /change:  tttttttttt tttttttgag atggagtctc actgtgttgc
Feature           /change:  ccaggctgga gtgcagtggc aggatcttgg ctcattgcaa
Feature           /change:  cctctgtctc ccaggttcga gcgattctcc tgactcagcc
Feature           /change:  tcctgagaag ttgggactct gggcgcgtgc cacaatgtct
Feature           /change:  ggctaatttt ttatgttttt agtaaagacg gtgtttcacc
Feature           /change:  gtgttagcca ggatggtctt gatctcctga cctcgtgatc
Feature           /change:  cgcccgcctc agcctcccat agtgctggga ttacaggtgt
Feature           /change:  gagccaccat gcctggcctt ttttcccccc ttttgagaca
Feature           /change:  gggtctccct ttgtcaccca ggctgaagtg cagtggcata
Feature           /change:  atcatggctt actgcagcct taaactccca ggctcaagtg
Feature           /change:  atcctcccac ctcagcctac aaatagctga gactacagat
Feature           /change:  atgtgccacc atgcccggct aatttttgta ttttctgtag
Feature           /change:  agacagggtt tgccatgtgg cccaggctgg tctcaaactt
Feature           /change:  gtgagcttga gcaatccgcc caccttggcc tcccaaagtg
Feature           /change:  ctgagattac aggcctgagc cactgaccct ggccaaattt
Feature           /change:  tttttctact agctactgag gctgccacat ctggatggaa
Feature           /change:  ctgagtggag ggggaaaaga atgaaaaact caaaagaatt
Feature           /change:  cccatgaggg tgtcttgctt tctctcctga gttacaatac
Feature           /change:  tttagcaaaa tcatgaggct ttagagatat ggtgtagtct
Feature           /change:  gcaaacttct taatgccctt acccacattt accatgtttc
Feature           /change:  ctggccttcc tctgtgtcaa ctcttagctc ttcctaatca
Feature           /change:  ttatttaata catgagtgag tttagtagtg atcatatttc
Feature           /change:  tcaggtcctt tagaagctgg aattttaaaa gaattagaag
Feature           /change:  gaggagtatg tgaattcttt ggagctcact gcctgacttg
Feature           /change:  cttatgacca ggaaaatcta tcccctgtat ctaattttaa
Feature           /change:  tttcatggtt aaatttgaga attgtggaaa ccaagttcca
Feature           /change:  caaggctatt ctcatatttc tcccaatttc tttttcagcc
Feature           /change:  aactccaagg atatgtatca cctttgactt aatttgcttt
Feature           /change:  ctctaaggga aaggggaaaa aatgttcaca tagctccact
Feature           /change:  gcaatgtttt ttataataga ggagagatat tgtaaataga
Feature           /change:  gactgccagc cagtttccac aaaaaaacga agagttcata
Feature           /change:  aatttgacat gtttgaaccc ataaagcatt ttctttgctt
Feature           /change:  ggaaccatta taaaagtaag tgagttttca ggctctatat
Feature           /change:  acattttaat tcctcacgtt ttatattgga gagttcggta
Feature           /change:  cagactgtcc attactgcac caaaagaatg agtgaactgt
Feature           /change:  tacctatagg gaaagaacac ttcttcttcc tgctgtttgg
Feature           /change:  gaaccatctc agtgtggcgt aatggttagg agtacagatt
Feature           /change:  ccagatcctg tttcttagat ttaaatcttg actctgccac
Feature           /change:  atactagctg tctgactgaa ccttggtttt tctgtgcttc
Feature           /change:  agtttcctca tctgtaaaac ggagataaca gtacttacct
Feature           /change:  catagagctg ttgtgaaaag tgatgactga atatgtaaaa
Feature           /change:  gcacctagaa cagtgcctgg cacatgctaa gtgctttgtt
Feature           /change:  cattattgtt gttattatgt aattttctct cagactgaga
Feature           /change:  gcactgttag tgacccaagt aaatttatag tttttaagta
Feature           /change:  cagaggaaaa ataaagccta ttttttgtta acagtcttaa
Feature           /change:  taaataataa aatggaataa agaaaccaag accccatctt
Feature           /change:  ctgtgaatat tagggctttt ttttttttga cagtcataaa
Feature           /change:  gatgttttca ctatggcatt tctatccctg tgtatatcca
Feature           /change:  aacatgtcct gaagaagaaa tgagatgttc caccaaaaac
Feature           /change:  acgtaagcag gaagcagctg ttctgctcag cttggcaggt
Feature           /change:  gttctttcct aattcttccc aagctgtgag tcagaaagtc
Feature           /change:  ctggaaggag ttgtaggaag ttgtagaggc tgggtcactg
Feature           /change:  acctaagaga aggcatcatt tggcccactg cacgtcctgg
Feature           /change:  cctattcacc aaagcccttc ctggctctga ctgccacacc
Feature           /change:  aggcagtggg tgaaatgctg gctttttcct taagaaattg
Feature           /change:  tgttctagtg ccaccaagag atgctgtaga gctggcttta
Feature           /change:  ccaatctcat gatgcttgct tggcaactct gaaaggtgac
Feature           /change:  tttggccaag aagaccttgt ggcaattctg caaattttat
Feature           /change:  acactcatat cttttagggt acaaaatgaa agaacaaatc
Feature           /change:  acaaagaaca atagatcctt caggagctga aggtaagaat
Feature           /change:  cttttatagc tattttaaca tatacagtga ctactttcta
Feature           /change:  ctagccaaat atcaaatttt acaactacca ccaagccaca
Feature           /change:  gattataggt ggtaacaact ccagaaatgt cctaactagg
Feature           /change:  aaaggtgctc atctagtatg catcggtatc caggataata
Feature           /change:  tgagttagaa ttttaaaaat gtcagtcatt caaaaatatt
Feature           /change:  tgaactgtga catcacagaa gtaattttat ggccttttaa
Feature           /change:  ggtaacaact taaaaagaga acagtactct ttttatatca
Feature           /change:  atgcctttac atttatttaa aaacagtcct aatgctttat
Feature           /change:  agttaaatgt catatgcaga tatgttcagg ctctaacata
Feature           /change:  taaagttcct aacttgacag gaaactactg aagattgtgt
Feature           /change:  acagcttaaa aaaaaaaata gggtaactat agtcttgatt
Feature           /change:  tttatgtata aattctatca ttctatattt taccatcaga
Feature           /change:  catatttcta ctcctttctt tgaagtatgc gaagtatctc
Feature           /change:  caactgcagc atgcaactca ttcatttgta atcaagacga
Feature           /change:  tagtttgaaa cacccaattg taatcagagc aacagttgac
Feature           /change:  ttccttttga tagcggagtt gaaaatcatt gcaattaata
Feature           /change:  aaatggggct attagaaatg gaaaacgaat aggatctaga
Feature           /change:  atgtaacttc atcatataaa tgatgagtgt ctttgttatc
Feature           /change:  aacacgttat taagaatggg caagatgtcc ttatatacta
Feature           /change:  gaagcttttg taaagtcatg tgtctattga taataaagat
Feature           /change:  tttcggaact gatgttctga gtgagactac aaaggatgct
Feature           /change:  ttaaaacgag tgatatctgg ccgggcatgg tggttcccac
Feature           /change:  ctatactccc agcactttcg gaggccaagg caggcagatc
Feature           /change:  acttgaggcc aagagttcga gaccagcctg gccaacatgg
Feature           /change:  tgaaacccct tctctactga aaatacaaaa attagctggg
Feature           /change:  catggcagtg catgcctgta atcccagcta ccctggaggc
Feature           /change:  tgaagcacga ggatcacttg aaccaaggag gcagaggttg
Feature           /change:  cagtgaactg agatcgcacc actgcactct agccttggca
Feature           /change:  acagagtgag accctgtctc aaaaaacaag caaacaacaa
Feature           /change:  caataaaacc agtgatgccc tgcaaaatga ggattgagag
Feature           /change:  acaagtcccc aacactatat tttttaattc ctgatgtttc
Feature           /change:  tttttaagtt acattttata ttctatttga agcatctata
Feature           /change:  gacacttctt ggacctcttc tatttttctt agtctatatt
Feature           /change:  tctatatttt catggtccta tagccaactc tttagacata
Feature           /change:  tccactcttc tgtatctcag catcccataa tgtttgatag
Feature           /change:  agggtaaaaa taacagagta tacacacaca cacacacaca
Feature           /change:  cacacacaca cacacacaga atctaccatc gtccccatcc
Feature           /change:  cctgctcctt ctgtctatct taacttgcaa atggcaggat
Feature           /change:  caatcaactg ccacctgccc aggtcagaca attatcctct
Feature           /change:  cttgcttcca ttacttcagc agcttttaat tggcctctgg
Feature           /change:  cctctagtct tatcctctcc agtctaatct ctgtacaatg
Feature           /change:  ctatagtaca gccacagtgc ctttttgttg ttgttgtcat
Feature           /change:  tacgctgttg tttttaattg cagtattata tacatgactt
Feature           /change:  aaacttacca tcctaaccat tcttaaatat acatttcatg
Feature           /change:  tattggttgg ttctcacatt gctataaaga actatctgag
Feature           /change:  actgggtagt ttataaagag aaaatgttta attgactcac
Feature           /change:  agttccatag gctgtacagg aggcatggcc agggaggcct
Feature           /change:  caggaaactt acaatcatgg cagaaggtga agtggaagca
Feature           /change:  agtacatctt cacatggtga caggaaagag agagagagag
Feature           /change:  agagagagag agagacagag caaagggaga agtgccacac
Feature           /change:  acttttaaac catcagatct catgagaact cactcagtgt
Feature           /change:  cacaagaaca gcaaggggga aatctgctcc catgatccaa
Feature           /change:  tcatctccca gcagctccct tccccaacat tgggaattat
Feature           /change:  aattcaacat gagatttggg tggggacaca gagccaaact
Feature           /change:  atatcagttc ccatactgct aagtacactc atattgttgt
Feature           /change:  gcaaccagtc tccaggattc ttttcatctt tcaaaactga
Feature           /change:  actctatact caataaacaa aaactgctca tccctccagc
Feature           /change:  ccctggcaac caccattctg ctttctatct ctatgagctt
Feature           /change:  gactgctcta gatactgcat tgaactggaa taatatagta
Feature           /change:  tttgtcctgt cgtgtctggc ttatttcact tagcattatg
Feature           /change:  tcctcaagct tcatccatgt tgtagtgcgt gtcagatttt
Feature           /change:  aaagctcagt aatatgccat cgtatttata gagtacattt
Feature           /change:  tgtttagtca ttcacctgtc aatggacaca ggttgctccc
Feature           /change:  actttttggc tgctgtgaat agtgccgttc aactgcttaa
Feature           /change:  aactctgtaa tggctgctga ttgctgttgg gataaaatct
Feature           /change:  catctcctta gtgaggttct tcaaggccct gaaggagcca
Feature           /change:  ggccccgctt actttcagct tcatccctga cacctttcat
Feature           /change:  tgcttgcttg ctttccttcc ttctttcttt ctttctctct
Feature           /change:  ctttttcttt ctttctttta tttctttttc tttctttctt
Feature           /change:  ttctttcttc tttctctttc tttcttcttt ctttctttta
Feature           /change:  tttcttctct ctctctcttt tagagagagg gtcttgccta
Feature           /change:  ggccggagtg cagtggcaca attatagctc actgcagcct
Feature           /change:  caaattccca ggttcaagcg atcttctcac ctcagcctcc
Feature           /change:  tgagtcgctg ggaccacaga cacgagacac caccctggct
Feature           /change:  acttcaaagc actgcaccca cccactcagt tccattgttg
Feature           /change:  cgtaggagct ccgtgaagtg catatttaag gactgcatcg
Feature           /change:  cccccatctt cacggtgtta tgtgtgcttc tgttactaaa
Feature           /change:  ctgctttttt atttttaagg acaaccaata acatcttact
Feature           /change:  tgttttggga tcttagcact ttgcatagta tcttttatag
Feature           /change:  gcatttgggt atttgtgttc tacatgcaga aatagagata
Feature           /change:  ttcagaattt gttttctgct atgagtgact ttttgtatag
Feature           /change:  ctttttgaag atgcatattt tacagcataa agcacggtat
Feature           /change:  ctagtttctc ctcccggagg atctgtgtcg ggtgctgagt
Feature           /change:  gaggccagga tgcggttggg ggcgcagtgt cctgagaagg
Feature           /change:  ggggtgggac ttggtgaggg gaggggacat gggactggag
Feature           /change:  aaagactgct tgggaagaag cagatcatgc aggagaacgg
Feature           /change:  tcagtctgaa aaggtgagtg gagagagaat gaagttctga
Feature           /change:  gtcacgggca ctgaagccag cagaactggg agcaaacaga
Feature           /change:  ggctgggatt gggtgctgtg tggcagagcc tggaagaaat
Feature           /change:  agcttagtca aggtacagac tcaatttgga tgcaaagaaa
Feature           /change:  gttgtaaaac tacattttat ctggaagtga ttttcttttt
Feature           /change:  ctttttattc ttcaaagcat gtaaaacaaa gttttctttt
Feature           /change:  tttttaattt tggacaaaat gtgttggctt gagtttcagc
Feature           /change:  tggacatatt tccatctaac atggcatcca gtagggtaat
Feature           /change:  ttgtgcaaag tacttagctc cctgctccta gtcacacagg
Feature           /change:  gctgtgtggc agctttcggc ttcagtccta aaacgccctc
Feature           /change:  agccactgaa gtcgccatgg tatggtaatg gtctgagatg
Feature           /change:  cctcagtctg tgcctctgaa tatgtcaggg aatcccacca
Feature           /change:  ccccccaccc cacacacatc cagactgctt atgaatccat
Feature           /change:  aatacttact caatacaaaa atgtctaaca gcctgtggat
Feature           /change:  tgtgcagaac agtaacagca agggtcttct tttcctacaa
Feature           /change:  gcgttgaaga ccaaggagag aatggaggac cctaaactgc
Feature           /change:  ccttgcttgg agctgcaagt tctctccctg ctgaagctga
Feature           /change:  ccctgcaggt cgactgctgc ttgggcctga agtgcctctc
Feature           /change:  agccaccagc agccaactct ttgaaaacat ggatttgggc
Feature           /change:  caggtgtggt ggctcacacc tgtaatccca acactttggg
Feature           /change:  aggccaaggc aggaggatca cctgagggca ggtgtttgag
Feature           /change:  accagcctgg ccaacatggt gaaaccccat ctctactaaa
Feature           /change:  aatacaaaaa ttagctcggt gtggtggcgc atgcctgtaa
Feature           /change:  tcccagctac ttgagaggct gaggcaggag aatcccttga
Feature           /change:  acctgggagg tggaggttgt tacagtgagc caagatcgtg
Feature           /change:  ccactgtcct ccagcctggc ctgggcaaca gagtgagaca
Feature           /change:  ctgtctcaaa aaaaaaaaaa aattaagaaa aaaaaataaa
Feature           /change:  caaaaaacaa aacaaacaaa aaaacacatg attgtgaacc
Feature           /change:  aaatcaagca aagaatctcc aggggggtag tgcctataaa
Feature           /change:  aggaatgtta cccccagata aaaacaaact atttagattc
Feature           /change:  tacatgacag aggaatttct cttgtgggta ggaatgttta
Feature           /change:  actaattcat tccttggctc tgctatgtgg tttaccctgg
Feature           /change:  tctcatgcac ccttagaagg gcatagatga ggtaacatgg
Feature           /change:  tttcttttca taatcttcat ccacgccttg tcatctggtt
Feature           /change:  tatggaagaa acctgtcaaa caagaaacgt tacctagtgg
Feature           /change:  caagatgtta ggacatgcag ttactaggag aaagtaaacg
Feature           /change:  gcctggaaga tgaaagacat ggccattttt ttaaggctgc
Feature           /change:  aactccacag gaggggtagc ttctcctgtt
Feature           /genomic_region: intron; 1
Feature         rna; 5
Feature           /dnalink: 4
Feature           /aalink: 6
Feature           /name: unknown
Feature           /inexloc: -9735
Feature         aa; 6
Feature           /rnalink: 5
Feature           /name: unknown
Age             33 mo
Sex             XX
Ethnic origin   Caucasoid; Kurdish
Parents         Consanguineous
//
//

This site is updated by Jouni Väliaho
© IBT Bioinformatics 1998-2013
Last modified 16.06.2011