Version 1.00 last updated 22 February, 2008 contains 3 public entries |
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Short description of the RASA1base : Basal cell carcinoma (BCC) is the most frequent skin cancer in the white population. BCCs mostly occur sporadically in relation to sun exposure, although their incidence is increased significantly in some rare genetic disorders. Mutations within the C-terminal SH2 domain (C-SH2) of the GTPase activating protein RasGAP have also been found in a subset of BCCs. RasGAP acts by enhancing the intrinsic GTPase activity of Ras, leading to the hydrolysis of bound GTP to GDP and down-regulation of Ras activity.  Other IBT bioinformatics services: Immunodeficiency Resource (IDR) Immunodeficiency Mutation Databases (MUTbase) IDdiagnostics Immunome Knowledge Base (IKB) - An integrated service for immunome research SH2base - Database for pathogenic SH2 domain mutations |
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