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PON-P, Pathogenic-or-Not Pipeline

PON-P is a machine learning-based method for predicting whether variants affect functions and thereby lead to diseases. PON-P portal allows submission and prediction into altogether 32 distinct tools. The current version analyses only missense variations i.e. aminoasid subtitutions.

PON-P prediction

Email (Please provide your e-mail address to get these results when ready)

 

Paste FASTA format sequence(s)

Empty lines are not allowed. Use only single one letter uppercase amino acid codes.
You can give multiple sequences. Please make sure that the header line starts with the unique sequence ID.

or upload sequences as a file

EXAMPLE

Paste variation(s) after corresponding FASTA sequence IDs

or upload variations as a file

EXAMPLE
Additional methods (because many of the services are run on third party servers the number of possible predictorselections is restricted to ten variant)
Notice:CUPSAT is out of use because the CUPSAT server is migrating.
Notice:Waltz server is not responding.
 
Tolerance prediction 
PON-P nsSNPanalyzer SIFT PhD-SNP Polyphen1 Polyphen2 SNAP Panther SNPs&GO
Stability change prediction 
Automute Cupsat Dmutant FoldX I-Mutant3 Mupro SCide SCPred SRide
Disorder prediction 
DisProt FoldIndex FoldUnfold GlobPlot IUPred metaPrDOS PrDOS RONN Spritz
Aggregation prediction 
Aggrescan Waltz Pasta
Localization prediction 
PROlocalizer WoLF-PSORT

 
  
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