The methods predicting the effects of missense mutations on protein stability either calculate free energy changes based on the 3D structure of the protein or predict the properties based on the amino acid sequence, using e.g. sequence conservation and physicochemical properties as parameters.
AUTO-MUTE |
http://proteins.gmu.edu/automute/AUTO-MUTE.html |
(Masso and Vaisman, 2008) |
CUPSAT |
http://cupsat.tu-bs.de/ |
(Parthiban, et al., 2006) |
Dmutant |
http://sparks.informatics.iupui.edu/hzhou/mutation.html |
(Zhou and Zhou, 2002) |
FoldX |
http://fold-x.embl-heidelberg.de:1100/cgi-bin/main.cgi |
(Guerois, et al., 2002) |
I-Mutant 2.0 |
http://gpcr2.biocomp.unibo.it/cgi/predictors/I-Mutant2.0/I-Mutant2.0.cgi |
(Capriotti, et al., 2005a; Capriotti, et al., 2005b) |
MuPRO |
http://www.ics.uci.edu/%7Ebaldig/mutation.html |
(Cheng, et al., 2006) |
PoPMuSiC |
http://babylone.ulb.ac.be/popmusic/ |
(Gilis and Rooman, 2000) |
SCide |
http://www.enzim.hu/scide/ide2.html |
(Dosztanyi, et al., 2003) |
SCpred |
http://www.enzim.hu/scpred/pred.html |
(Dosztanyi, et al., 1997) |
SRide |
http://sride.enzim.hu/ |
(Magyar, et al., 2005) |
iPTREE-STAB |
http://210.60.98.17/IPTREEr/iptree.htm |
(Huang et al.,
2007) |
Eris |
http://dokhlab.unc.edu/tools/eris/ |
(Yin et al., 2007) |
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