MPObase: Myeloperoxidase deficiency

Version 1.0 last updated 18 June, 2007 contains 39 public entries


Curated:	Mauno Vihinen
Maintained by:	Jouni Väliaho
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Short description of the MPObase :

Myeloperoxidase (MPO) deficiency is a common inherited disorder linked to increased susceptibility to infection and malignancy. Myeloperoxidase (MPO) enzyme is expressed in the azurophilic granules of neutrophils and in the lysosomes of monocytes. Its major role is to aid in microbial killing. MPO deficiency can be divided into two subgroups: primary (congenital) and secondary (acquired). Primary MPO deficiency has a genetic origin, present varying degree of severity in more than one family member, and involves both the neutrophil and monocyte lineages.

Other IBT bioinformatics services:
Immunodeficiency Resource (IDR)
Immunodeficiency Mutation Databases (MUTbase)
IDdiagnostics
Immunome Knowledge Base (IKB) - An integrated service for immunome research
SH2base - Database for pathogenic SH2 domain mutations

IDbases are linked to University of California Santa Cruz (UCSC) genome browser: MPObase