IRAK4base: IRAK4 deficiency

Version 1.1 last updated 21 August, 2008 contains 15 public entries


Curated:	Mauno Vihinen
Maintained by:	Jouni Väliaho
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Short description of the IRAK4base :

NEMO, IKBA and IRAK4 (IL-1-receptor-associated kinase-4) mutations result in novel primary immunodeficiencies affecting the NF-kB signalling pathway. The infectious phenotypes associated with each of the three genetic disorders are markedly different. IRAK4 deficiency patients are susceptible to pyogenic bacteria and resistant to most other common microorganisms, including mycobacteria, viruses and fungi.

Other IMT services:
Immunodeficiency Resource (IDR)
Immunodeficiency Mutation Databases (MUTbase)
IDdiagnostics
Immunome Knowledge Base (IKB) - An integrated service for immunome research
SH2base - Database for pathogenic SH2 domain mutations

IDbases are linked to University of California Santa Cruz (UCSC) genome browser: IRAK4base