IL2RAbase: Interleukin-2 receptor α deficiency

Version 1.1 last updated 21 August, 2008 contains 2 public entries


Curated:	Mauno Vihinen
Maintained by:	Jouni Väliaho
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Short description of the IL2RAbase :

It is a severe combined immunodeficiency, with absence of CD1 and of IL2RA expression on cortical thymocyte. It is characterized by decreased numbers of peripheral T cells but normal B-cell development. Extensive lymphocytic infiltration of tissues, including lung, liver, gut, and bone accompanied by tissue atrophy and inflammation. The absence of CD25 affected the differentiation of thymocytes.

Other IMT services:
Immunodeficiency Resource (IDR)
Immunodeficiency Mutation Databases (MUTbase)
IDdiagnostics
Immunome Knowledge Base (IKB) - An integrated service for immunome research
SH2base - Database for pathogenic SH2 domain mutations

IDbases are linked to University of California Santa Cruz (UCSC) genome browser: IL2RAbase