FASLGbase: Autoimmune lymphoproliferative syndrome, type 1B (ALPS1B)

Version 1.0 last updated 15 June, 2007 contains 2 public entries


Curated:	Mauno Vihinen
Maintained by:	Jouni Väliaho
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Short description of the FASLGbase (previously known as TNFSF6base) :

Defects in TNFSF6 are a cause of autoimmune lymphoproliferative syndrome (ALPS), a childhood syndrome. There are several types of ALPS: type I ALPS (a and b) is associated with Fas and Fas ligand defects and type II ALPS is caused by defects in other apoptosis genes (CASP10). ALPS can be caused by autosomal recessive (ALPS 0) or by autosomal dominant inheritance of Fas mutations (ALPS Ia) and Fas ligand (ALPS Ib).

Other IBT bioinformatics services:
Immunodeficiency Resource (IDR)
Immunodeficiency Mutation Databases (MUTbase)
IDdiagnostics
Immunome Knowledge Base (IKB) - An integrated service for immunome research
SH2base - Database for pathogenic SH2 domain mutations

IDbases are linked to University of California Santa Cruz (UCSC) genome browser: FASLGbase